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Patho Test 3-me > Chapter 27- Alterations of Leukocyte, Lymphoid, and Hemostatic Function > Flashcards

Chapter 27- Alterations of Leukocyte, Lymphoid, and Hemostatic Function Flashcards

1
Q

leukocytosis is found in all of the following except :

a. inflammatory responses
b. allergic responses
c. bacterial infections
d. bone marrow depression

A

d. bone marrow depression

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2
Q

What is a notable characteristic of infectious mononucleosis:

a. short incubation period of less than a week
b. affects preteens
c. presence of atypical lymphocytes
d. widespread invasion of T cells

A

c. presence of atypical lymphocytes

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3
Q

Which of the following likely is not associated with leukemia:

a. radiation
b. hereditary abnormalities
c. polycythemia vera
d. chloramphenicol
e. increased production of other hematopoietic cells

A

e. increased production of other hematopoietic cells

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4
Q

The cell from which all most often arises is a:

a. stem cell
b. T cell
c. B cell
d. monoblast

A

c. B cell

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5
Q

Signs and symptoms of acute leukemia include all of the following except:

a. splenomegaly
b. petechiae
c. lymphadenopathy
d. polycythemia
e. pallor

A

d. polycythemia

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6
Q

CML is characterized by its:

a. high blastocyst numbers
b. high incidence in children
c. association with presence of hyperuricemia
d. survival time of weeks to months

A

c. association with presence of hyperuricemia

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7
Q

a bone marrow analysis reveals an abnormality high number of lymphoblast. The likely diagnosis is:

a. multiple myeloma
b. ALL
c. CML
d. CLL

A

b. ALL

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8
Q

Clinical manifestations of multiple myeloma include all of the following except:

a. bone pain
b. decreased serum calcium
c. M protein
d. renal damage
e. pathological fractures

A

b. decreased serum calcium

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9
Q

Thrombocytopenia may be caused by all of the following except:

a. an IgG autoantibody
b. drug hypersensitivities
c. viruses that stimulate platelet production
d. bacterial infections that consume platelets
e. viruses that destroy circulating platelets

A

c. viruses that stimulate platelet production

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10
Q

A thrombocytopenia with a platelet count of 40,000/mm^3 likely will cause:

a. hemorrhage from minor trauma
b. spontaneous bleeding
c. death
d. polycythemia

A

a. hemorrhage from minor trauma

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11
Q

Thromboembolic disorders can be caused by all of the following except:

a. injured vessel walls
b. tissue damage that releases excessive TF
c. obstructed blood flow
d. deficient dietary intake of vitamin K
e. polycythemia

A

d. deficient dietary intake of vitamin K

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12
Q

DIC is associated with:

a. endothelial damage
b. the activation of factor X
c. the release of tissue factor
d. gram positive sepsis
e. a,b,c are correct

A

e. a,b,c are correct

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13
Q

Essential thrombocythemia exhibits:

a. fewer megakaryocytic than normal in the marrow
b. thrombosis
c. erythromyalgia
d. Both b& c are correct
e. a,b,c are correct

A

d. Both b& c are correct

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14
Q

In DIC plasmin:

a. begins to degrade fibrin before a stable clot develops
b. complexes with factor VII
c. activates factor V
d. All of the above are correct

A

a. begins to degrade fibrin before a stable clot develops

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15
Q

The manifestations of leukemia include:

a. petechial hemorrhage
b. hyperuricemia
c. weight loss
d. night sweats
e. all of the above

A

e. all of the above

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16
Q

Philadelphia chromosome is observed in:

a. AML/CML
b. AML/CLL
c. ALL/CLL
d. ALL/CML

A

d. ALL/CML

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17
Q

B cells fail to mature into plasma cells in:

a. AML
b. ALL
c. CML
d. CLL

A

d. CLL

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18
Q

Death in MM is most commonly due to:

a. infection
b. hypercalcemia
c. anemia
d. pathologic fractures

A

a. infection

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19
Q

Acute ITP is:

a. more common in individuals older than 40 years of age
b. usually preceded by a viral infection
c. often manifested by menorrhagia
d. more common in females
e. c & d are correct

A

b. usually preceded by a viral infection

20
Q

A deficiency in vitamin k is caused by:

a. lack of clotting factor VII
b. impaired platelet function
c. altered gut flora
d. a & b are correct

A

c. altered gut flora

21
Q 
1. Which of the following terms best describes a higher-than-normal white blood cell count?
A. Leukopenia
B. Leukocytosis
C. Granulocytosis
D. Neutrophilia
A

B. Leukocytosis

22
Q 
2. Which of the following is NOT a cause of neutropenia?
A. Decreased production
B. Reduced survival
C. Abnormal distribution
D. Increased vitamin storage
A

D. Increased vitamin storage

23
Q 
3. Which of the following is NOT a cause of eosinophilia?
A. Asthma
B. Prolonged infection
C. Atopic dermatitis
D. Eczema
A

B. Prolonged infection

24
Q
  1. Which of the following is a TRUE statement regarding infectious mononucleosis?
    A. It is characterized by granulocytosis.
    B. It is commonly caused by Epstein-Barr virus.
    C. It usually affects older adults.
    D. It is caused by the poxvirus family.
A

B. It is commonly caused by Epstein-Barr virus.

25
Q 
5. Which of the following forms of leukemia is the most common in children?
A. Acute lymphoblastic leukemia (ALL)
B. Acute myelogenous leukemia (AML)
C. Chronic lymphocytic leukemia (CLL)
D. Chronic myelogenous leukemia (CML)
A

A. Acute lymphoblastic leukemia (ALL)

26
Q 
6. Which molecular anomaly with acute lymphoblastic leukemia carries the worst prognosis?
A. TEL
B. AML1
C. LYL
D. Philadelphia chromosome
A

D. Philadelphia chromosome

27
Q 
7. Which of the following cells proliferate in multiple myeloma?
A. Lymphocytes
B. Plasma cells
C. Eosinophils
D. Granulocytes
A

B. Plasma cells

28
Q 
8. Which of the following is NOT a condition that causes lymphadenopathy?
A. Neoplastic disease
B. Inflammatory condition
C. Lipid storage disease
D. Cardiac disease
A

D. Cardiac disease

29
Q
  1. Which of the following is a TRUE statement regarding lymphoma?
    A. The malignancy occurs in the bone marrow.
    B. It is the result of injury to the RNA of a lymphocyte.
    C. It usually starts in the lymph nodes of the stomach or intestines.
    D. Incidence rates are not associated with age or gender.
A

C. It usually starts in the lymph nodes of the stomach or intestines.

30
Q
  1. Which of the following is a TRUE statement regarding Hodgkin lymphoma?
    A. Incidence peaks in the early 20s through the 30s and then later in life.
    B. Incidence is greater in blacks.
    C. Incidence is increased in economically disadvantaged countries.
    D. There is an increase in plasma cells.
A

A. Incidence peaks in the early 20s through the 30s and then later in life.

31
Q 
11. Which of the following is an indicator of poorer prognosis for Hodgkin lymphoma?
A. Female gender
B. Increased white count
C. Increased hemoglobin
D. Increased lymphocyte count
A

B. Increased white count

32
Q
  1. Which of the following is a TRUE statement regarding Burkitt lymphoma?
    A. It is a type of Hodgkin lymphoma.
    B. It is common in the United States.
    C. It is a fast-growing tumor of the jaw and facial bones.
    D. It is associated with HIV infection.
A

C. It is a fast-growing tumor of the jaw and facial bones.

33
Q 
13. Which of the following is NOT one of the current criteria for overactive spleen?
A. Anemia
B. Cellular bone marrow
C. Splenomegaly
D. Leukocytosis
A

D. Leukocytosis

34
Q 
14. At which level of platelets can spontaneous bleeding occur?
A. Greater than 100,000/mm3
B. Between 50,000 and 75,000/mm3
C. Between 20,000 and 50,000/mm3
D. Between 10,000 and 15,000/mm3
A

D. Between 10,000 and 15,000/mm3

35
Q 
15. Which of the following is the most common cause of drug-induced thrombocytopenia?
A. Heparin
B. Thiazides
C. Estrogens
D. Ethanol
A

A. Heparin

36
Q
  1. Which of the following is TRUE regarding immune thrombocytopenic purpura (ITP)?
    A. It is an immune process involving autoantibodies.
    B. The chronic form has a higher incidence in adolescence.
    C. It starts with massive bleeding from the nose and mouth.
    D. Intracranial bleeding is common.
A

A. It is an immune process involving autoantibodies.

37
Q 
17. Which of the following is NOT a true statement regarding acquired idiopathic thrombotic thrombocytopenic purpura (TTP)?
A. It is caused by platelet aggregates.
B. It is more common in females.
C. The most common age group is infants.
D. Its incidence is increasing.
A

C. The most common age group is infants.

38
Q 
18. Which of the following factors is NOT regulated by vitamin K?
A. Protein C
B. VII
C. VIII
D. X
39
Q
  1. Which of the following is NOT associated with disseminated intravascular coagulation?
    A. Procoagulant inhibition
    B. Fibrinolytic activity
    C. Consumption of platelets and clotting factors.
    D. End organ damage
A

A. Procoagulant inhibition

40
Q 
20. Which of the following is NOT one of the three characteristics of the triad of Virchow?
A. Injury to endothelium
B. Abnormalities of blood flow
C. Hypercoagulability of the blood
D. Decreased clotting factors
A

D. Decreased clotting factors

41
Q 
Match the leukocytic alteration with the cause.
Eosinophilia
a. immune deficiencies
b.  allergic disorders
c. radiation
d. early stages of infection
e. AIDS
f. surgical stress
g. acute viral infections
A

b. allergic disorders

42
Q 
Match the leukocytic alteration with the cause.
Granulocytosis
a. immune deficiencies
b.  allergic disorders
c. radiation
d. early stages of infection
e. AIDS
f. surgical stress
g. acute viral infections
A

d. early stages of infection

43
Q

Match the characteristic with the malignant lymphoma
Localized nodal involvement
a. Hodgkin lymphoma
b. non-Hodgkin lymphoma

A

a. Hodgkin lymphoma

44
Q

Match the characteristic with the malignant lymphoma
Reed-Stenberg cells
a. Hodgkin lymphoma
b. non-Hodgkin lymphoma

A

a. Hodgkin lymphoma

45
Q

Match the characteristic with the malignant lymphoma
Pleural effusion
a. Hodgkin lymphoma
b. non-Hodgkin lymphoma

A

b. non-Hodgkin lymphoma

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