Chapter 26 Phatho Flashcards

1
Q
  1. What interstitial lung disease also goes by?
A

ILD, diffuse interstitial lung disease, fibrotic interstitial lung disease, pulmonary fibrosis, pneumoconiosis.

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2
Q
  1. ILD refers to?
A

a broad group of inflammatory lung disorders

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3
Q
  1. ILD can be?
A

acute, subacute, or chronic inflammatory inflammatory infiltration of alveolar walls by cells, fluid, and connective tissue

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4
Q
  1. If ILD is left untreated it can develop into
A

irreversible pulmonary fibrosis.

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5
Q
  1. Anatomic alteration of the lungs w/ ILD?
A
  1. destruction of the AC membrane
  2. fibrotic thickening of the respiratory bronchioles, alveolar ducts, and alveoli.
  3. granulomas
  4. honeycombing and cavity formation
  5. fibrocalcific pleural plaques - mainly from asbestosis
  6. bronchospasm
  7. excessive bronchial secretions , caused by inflammation
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6
Q
  1. Groups of ILD etiology
A
  1. occupational/environmental
  2. connective tissue disease
  3. idiopathic interstitial pneumonia
  4. specific pathology
  5. miscellaneous
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7
Q
  1. What are the Pathologic or Structural changes?
A
  • Destruction of the alveoli and adjacent pulmonary capillaries? in Exam
  • Fibrotic thickening of the respiratory bronchioles, alveolar dusts, and alveoli? in Exam
  • Granulomas
  • Honeycombing or cavitation formation.
  • Fibrocalcific pleural plaques (asbestosis)
  • Bronchospasm.
  • Excessive bronchial secretions (Inflammation in airways
    only)
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8
Q
  1. What are the Etiology and Epidemiology?

Interstitial lung Diseases of known causes or Associations:

A

Occupational, Environmental, and Therapeutic Exposures:-

  • Inorganic particulate dust exposure.
  • Coal dust
  • Silicosis
  • Beryllium
  • Organic material exposure.
  • Medications and illicit drugs
  • Radiation therapy.
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9
Q
  1. What is the SYSTEMIC DISEASES?
A

Connective Tissue Diseases (Collagen Vascular)

  • Scleroderma
  • Rheumatoid arthritis
  • Sjogren’s syndrome
  • Polymyotis-dermatomyositis.
  • Systemic lupus erthematosus.
  • Sarcoidosis.
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10
Q
  1. What are Idiophathic Interstitial Pneumonias?
A
  • Idiopathic Pulmonary fibrosis.
  • Cryptogenic Organizing Pneumonia.
  • Lymphocytic Interstital Pneumonia
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11
Q
  1. What is the Specific Pathology?
A
  • Lymphangioleiomyomatosis (LAM)
  • Pulmonary Langerhans Cell Histiocytosis.
  • Pulmonary Alveolar Proteinosis.
  • Pulmonary Vasculitides.
    . Wegener’s granulomatosis
    . Churg-Strauss syndrome.
    . Lymphomatoid granulomatosis
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12
Q
  1. What is Miscellaneous Diffuse Interstitial Lung Diseases?
A
  • Goodpasture’s Syndrome
  • Idiopathic Pulmonary Hemosiderosis.
  • Chronic Eosinophilic Pneumonia
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13
Q
  1. What is General Management of Interstitial Lung Disease?
A
  • Corticosteroids
  • O2 Therapy
  • Mechanical ventilation
  • Plasmaphereis (Goodpasture’s Syndrome)
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