Chapter 24: Urinary System Flashcards
processes that occur as filtrate is converted to urine:
- elimination of metabolic wastes
- regulation of ion levels
- regulation of pH balance
- regulation of blood pressure
- elimination of biologically active molecules
other functions of the kidney
- formation/conversion of calcitriol from vit. D
- production and release of erythropoietin
- potential to engage in gluconeogenesis
filtrate
- 180 L/day
- filtered sample of plasma with small solutes and minimal protein
- caught within capsular space and funneled into PCT
- materials not filtered remain in blood
filtrate occurs in the
renal corpuscle
tubular fluid
modified filtrate in the process
tubular fluid flows through
- PCT
- nephron loop
- DCT
- enters collecting tubules
- empties into collecting ducts
urine
final product for elimination
urine flows through
- papillary duct
- minor calyx
- major calyx
- renal pelvis
- ureter
- urinary bladder
- urethra
glomerular filtration
the movement of substances from the blood within the glomerulus into the capsular space
tubular reabsorption
the movement of substances from the tubular fluid back into the blood
tubular secretion
the movement of substances from the blood into the tubular fluid
most tubular reabsorption occurs at the
PCT
tubular secretion is ____________ at the DCT
highly variable
___________ strongly affect the DCT
hormones
filtration membrane
- composed of three sandwiched layers
- to enter filtrate, must pass through three layers
filtration slits are the
gaps between the podocytes
pedicels
processes on podocytes that wrap around the glomerulus to support the capillary wall
holes within the glomerular capillaries are called
fenestrations
filtration membrane can be damaged by high
blood pressure
Should formed elements be in the filtrate?
no
filtrate includes
- water
- glucose
- amino acids
- ions
- urea
- some hormones
- vitamins B and C
- ketones
- very small amounts of protein
glomerular hydrostatic pressure (HPg)
blood pressure in the glomerulus that pushes water and some solutes out of the blood into the capsular space
- driving force
- usually 60 mmHg
blood colloid osmotic pressure (OPg)
pressure of albumin in blood
- opposes filtration
- osmotic pressure exerted by dissolved solutes
- usually 32 mmHg
capsular hydrostatic pressure (HPc)
fluid pressure in the nephron
- detects any obstructions in the nephron or urinary tract
- opposes filtration
- usually 18 mmHg
finding the net filtration pressure (NFP)
HPg - (OPg + HPc) = NFP
average of NFP
10 mmHg
glomerular filtration rate (GFR)
rate at which the volume of filtrate is formed
increased HPg and NFP leads to
- increases GFR
- decreases filtrate reabsorption
- more solutes and H2O remain in tubular fluid and urine