Chapter 2 part 2 Genetics Flashcards
Genes
Contain instructions for making proteins
Genome
inherited characteristic instructions
Proteins
Cellular functions
Mutations
May lead genes to produce abnormal proteins
Chromosomes
23 pairs
Organized genome
Telomeres
Ends of chromosomes that are repeated strands of DNA, cannot replicate without these
Single Nucleotide Polymorphism (SNPs)
Genetic variation
Can be used to track inheritance of disease
Can predict individual response to some drugs
Genome-wide Linkage Study
Searches the families
Genome-wide Association Study
Searches the genome
Programmed Aging Theories
- Believe that aging and death are built into the hard writing of all organisms genetic code
- Longevity is an inherited species-specific trait
Gompertz Function / Curve
- Variations in the life span among species are clearly illustrated when age is plotted against death rates
- Longevity is an inherited species-specific trait (Humans 25%)
- “Aging Genes”
Human Life span
122
How much of longevity in humans is inherited
25%, rest is lifestyle related
Good Genes Gone Bad Theory
Aging genes take over in the post- reproductive years and lead to the ultimate deconstruction of the organism
Replicative Senescence
Loss of ability of cells to reproduce
cellular senescence is 50