chapter 12- disorders Flashcards
decreased platelet levels
thrombocytopenia
decreased platelet levels can be caused by? (3)
decreased platelet production
increased destruction
platelets used up in forming clots
platelet disorders are caused by two main categories:
decreased platelet levels (thrombocytopenia)
or
impaired platelet function
DIC
disseminated intravascular coagulation
“you clot so much you can’t clot anymore”
DIC definition:
disturbance of hemostasis where we get wide spread coagulation and bleding
T or F
Platelet disorders are bleeding disorders
True
The 2 coagulation disorders:
- vWF disease
2. Hemophilia A
what happens in vWF coagulation disease?
- platelet unable to bind to collagen
- spontaneous bleeding from mucous membranes
what causes vWF coagulation disease?
defects in Factor VIII (8), deficient in vWF, so cant bind platelets to collagen
both vWF and Hemophilia A are deficient in what?
Factor VIII (8)
Acquired coagulation disorders: (2)
Liver disease- cant make clotting factors
Vitamin K deficiency- deficiency in gut flora to make VK
Immune thrombocytopenic Purpura (ITP)
an autoimmune disease that results in platelet antibody formation against GP IIb/IIIa….and excess destruction of platelets
Immune Thrombocytopenic purpura (ITP) manifests as:
excessive bleeding, purpura, petechia, and low platelet.
splenomegaly in serious cases
enlarged spleen from dead or dying platelets
splenomegaly
diagnosis of ITP:
platelet levels below 20,000-30,000
