chapter 12 Flashcards
The Endocrine System Introduction Maintains what.
Maintains internal environment (homeostasis)
Hypothalamus
Hypothalamus: sends chemical signals to pituitary
Endocrine glands
Ductless
Secrete hormones directly into bloodstream
PINEAL
PINEAL
(melatonin)
THYROID
THYROID
(Thyroid Hormone)
PARATHYROID
PARATHYROID
(Parathyroid Hormone)
(Calcitonin)
ADRENAL
ADRENAL
(Epinephrine,
Norepinephrine,
Cortisol, Aldosterone)
THYMUS
THYMUS
(Thymoxin)
PANCREAS
PANCREAS
(Insulin)
The Functions of Hormones
Control cellular respiration, growth and reproduction
Control body fluids and electrolyte balance
Control secretion of other hormones
Control behavior patterns
Regulate reproductive cycles, growth and development
Chemical control functions as negative feedback loop
Thermostat turns furnace on when temperature falls below set point
Hormones function similarly
The Classification of Hormones
1. Modified amino acids Epinephrine, oxytocin 2. Proteins Insulin, growth hormones 3. Steroid Cortisol, estrogen
Modified amino acids
- Epinephrine
2. oxytocin
Proteins
- Insulin,
2. growth hormones
Steroid
- Cortisol,
2. estrogen
The Hypothalamus of the Brain
Nerve cells produce chemical signals
Releasing hormones
Releasing inhibitory hormones
Controlled by negative feedback from endocrine system
Nerve cells produce chemical signals
Nerve cells produce chemical signals
Releasing hormones
Releasing inhibitory hormones
Controlled by negative feedback from endocrine system
The Master Gland:
The Master Gland: Hypothalamus
The Major Endocrine Glands and Their Hormones
The Major Endocrine Glands and Their Hormones Pituitary Gland Thyroid Gland Parathyroid Glands Adrenal Glands Pancreas Testes & Ovaries Thymus Gland Pineal Gland
The Major Endocrine Glands
The Anterior Pituitary Gland (Hypophysis)
The Posterior Pituitary Gland
The Anterior Pituitary Gland (Hypophysis) and Its Hormones
Prolactin (PRL)
Thyroid Stimulating Hormone (TSH)
Adreno-corticotrophin Hormone (ACTH)
Growth Hormone (GH)
Melanocyte Stimulating Hormone (MSH)
Follicle Stimulating Hormone (FSH)
Luteinizing Hormone (LH)
The Anterior Pituitary Gland: (FLAT PiG M)
- F-ollicle-stimulating hormone
- L-uteinizing hormone (LH)
- A-drenocorticotropic hormone (ACTH):
- T-hyroid-stimulating hormone (TSH):
- P-rolactin (Lactogenic hormone):
- G-rowth hormone (GH):
- M-elanocyte-stimulating hormone (MSH):
Sex Hormones:
- Follicle-stimulating hormone (FSH)
2. Luteinizing hormone (LH)
Follicle-stimulating hormone (FSH)
Follicle-stimulating hormone (FSH)
Females
Stimulates ovarian follicle development
Males
Stimulates sperm cell production
Luteinizing hormone (LH)
Luteinizing hormone (LH) Females- Stimulates OVULATION and Progesterone production
Males- Testosterone production
Adrenocorticotropic hormone (ACTH):
Adrenocorticotropic hormone (ACTH): stimulates adrenal cortex to secrete:
- Glucocorticosteroids (Steroids, Cortisol)
- Androgens (Estrogen & Testosterone)
- Mineralocorticoids (Aldosterone)
Thyroid-stimulating hormone (TSH):
Thyroid-stimulating hormone (TSH): stimulates thyroid to secrete:
TH (Thyroid Hormones)
Prolactin (Lactogenic hormone):
Prolactin (Lactogenic hormone):
Stimulates: milk production in females
May cause decrease in male sex hormones
Growth hormone (GH):
Growth hormone (GH): cell metabolism and growth
Decreased production of growth hormone
DWARFISM: childhood
increased production of growth hormone
Increased production
GIGANTISM: childhood
ACROMEGALY: post puberty/adult
Growth hormone is controlled by what?
Controlled by two releasing hormones from hypothalamus
Melanocyte-stimulating hormone (MSH):
Melanocyte-stimulating hormone (MSH): stimulates melanocytes to secrete:
Melanin hormone
Antidiuretic hormone (ADH)
Antidiuretic hormone (ADH) water reabsorption in kidney tubules Deficiency results in Diabetes Insipidus Regulated through osmoreceptors Dehydration causes water conservation
Oxytocin
Oxytocin
- Contraction of uterine smooth muscles
- Lactation (Constriction of mammary gland cells )
*** DIFFERENT FROM PROLACTIN:
Prolactin: milk PRODUCTION
Oxytocin: milk LET DOWN
- Given after childbirth to constrict blood vessels to minimize risk of hemorrhage
F- FSH (Follicle Stimulating Hormone)
Ovaries, Testes
Stimulates ovarian follicle & sperm cell production
L- LH (Luteinizing Hormone)
Ovaries, Testes
Stimulates ovulation and progesterone & testosterone production
A- ACTH (Adrenocorticotrophic Hormone)
Adrenal Gland Cortex
Stimulates Adrenal Gland
T- TSH (Thyroid Stimulating Hormone)
Thyroid Gland
Stimulates Thyroid Gland
P- Prolactin
Mammary Gland
Milk production
G- GH (Growth Hormone)
Bone, Muscles, Liver, Tissues
Promote cell metabolism & growth
M- MSH (Melanoctye Stimulating Hormone)
Melanocytes
Stimulates Melanocytes
A- ADH (Anti- Diuretic Hormone)
Kidneys
Reabsorb Water
O- Oxytocin
- Mammary Gland
- Uterus
- Lactation, Uterus contraction
The Thyroid Gland Hormones:
Thyroxine (T4):
Triiodothyronine (T3):
Calcitonin:
Thyroxine (T4):
Thyroxine (T4): metabolism
Triiodothyronine (T3):
Triiodothyronine (T3): metabolism
Calcitonin:
Calcitonin: regulation of calcium and phosphate concentration
HYPERTHYROIDISM
HYPERTHYROIDISM
(Excessive Thyroid Hormones)
Weight loss, fatigue, palpitations of the heart, nervousness, and slight tremors in the hands
Graves Disease
Graves Disease Above symptoms PLUS: - Goiter (enlarged thyroid gland) - Exophthalmos (abnormal protrusion of the eyes)
Tx: Radioactive Iodine and other medications
HYPOTHROIDISM
HYPOTHROIDISM
(Thyroid Hormones Deficiency)
HYPOTHROIDISM in KIDS
KIDS: Cretinism (mental retardation & growth)
HYPOTHROIDISM in ADULTS:
ADULTS: metabolism -> Chronic fatigue & Weight Gain; Myxedema (an accumulation of fluid in subcutaneous tissues)
treatment of hypothyroidism
Tx: Thyroid hormones
Position of the parathyroid glands:
Position of the parathyroid glands:
within the posterior thyroid gland
The Parathyroid Glands, Their Hormones and Some Disorders
Chief cells- secrete parathormone (PTH) PTH stimulates bone cell release of calcium and phosphate Hyperparathyroidism Breakdown of bone matrix Hypoparathyroidism Low calcium level in blood
Diabetes insipidus
problems regulating ADH
the adrenal glands are located where?
Located on top of each kidney
Adrenal cortex hormones:
Adrenal cortex hormones: Glucocorticoids (steroids) i.e. Cortisol Mineralocorticoids i.e. Aldosterone Androgens i.e. Testosterone
The Adrenal Glands disorders
- Addison’s Disease: LACK of adrenal cortex hormones
2. Cushing’s Syndrome: TOO MUCH adrenal cortex hormones
Cushing’s Syndrome
-Cushing’s Syndrome Chronic Excessive Cortisol Symptoms: M & M Man: Central Obesity, Red, Moon face, with skinny extremities Immune system - High Blood Pressure
Stress
Stress
Excessive Epinephrine ( blood glucose)
Excessive Cortisol ( fat release)
Chronic symptoms: includes Depression, Obesity, fatigue, decrease in Immune system
Aldosteronism
Aldosteronism Excessive Aldosterone Symptoms: HIGH BLOOD PRESSURE (due to salt & water retention) low blood K+ and high blood pH
Islets of Langerhans Cells:
Islets of Langerhans Cells:
Beta cells: insulin production
Alpha cells: glucagon production
Blood glucose levels regulated by negative feedback
Pancreas Disorders
Disorders
Low blood glucose: Acidosis
High blood glucose: excess kidney production, Dehydration
Diabetes mellitus: insufficient insulin production
Key Endocrine System Disorders
Diabetes Mellitus (Pancreas)
or no insulin
Hyperglycemia, hyperglucosuria, polyuria, polydipsia
Tx: Drugs that decrease blood sugar; Insulin (if severe)
***Diabetes Mellitus DOES NOT = Diabetes Insipidus
Diabetes Insipidus (Kidneys)
or no Anti- diuretic Hormone (ADH)
Polyuria & polydipsia leading to SEVERE DEHYDRATION
Tx: ADH
Diabetes Mellitus (Pancreas)
Diabetes Mellitus (Pancreas)
or no insulin
Hyperglycemia, hyperglucosuria, polyuria, polydipsia
Tx: Drugs that decrease blood sugar; Insulin (if severe)
***Diabetes Mellitus DOES NOT = Diabetes Insipidus
Diabetes Insipidus (Kidneys)
Diabetes Insipidus (Kidneys)
or no Anti- diuretic Hormone (ADH)
Polyuria & polydipsia leading to SEVERE DEHYDRATION
Tx: ADH
Testes:
Testes: Testosterone
Development of male reproduction structures
Development of male sex characteristics
Ovaries: Estrogen and Progesterone
Development of female reproductive organs
Development of female sex characteristics
Control menstrual cycle
Ovaries:
Ovaries: Estrogen and Progesterone
Development of female reproductive organs
Development of female sex characteristics
Control menstrual cycle
The Thymus Gland is located behind what
Located behind the sternum
The thymus gland secretes
Secretes Thymosin
The thymus gland is important for
Important for T-cell production (Immune Response)
the thymus gland does what as we age
Thymus shrinks as we age
The Pineal Gland is located where
Located in the brain near the thalamus
Hormones in the penal gland
- Melatonin
2. Serotonin
Melatonin
Melatonin
Inhibits reproductive functions
Regulates body rhythms
Circadian Rhythm
Serotonin
Serotonin: neurotransmitter and vasoconstrictor
Stimulates smooth muscle contractions
Seasonal Affective Disorder (SAD)
Seasonal Affective Disorder (SAD)
Due to overproduction of melatonin (and decreased serotonin) that occurs in climate zones that have cloudy winter months with little bright sunshine (i.e. The state Washington)
Type of DEPRESSION
Treatment: Bright Light, Medications, &/ or Psychotherapy