Chap 6: Quiz Glycolysis, Gluconeogenesis and Pyruvate Flashcards
Basic formula for carbohydrates
Cx(H2O)x
Aldehydes vs Ketones
Aldoses vs. Ketoses
Glycosidic Bonds
linkages that join monosaccharides to each other
(can occur through amines or hydroxyls)
Metabolic Pathway
the process when a small molecule (metabolite) is transformed into a different molecule through a series of enzymatic reactions
Glycolysis
One molecule of glucose (six carbons) is catabolized into two pyruvates (three carbons)
Glycolysis provides energy
Two ATP and two NADH/H+ generated
Gluconeogenesis
Pyruvate into glucose (as well as lactate, glycerol and other a.a.)
Requires 6 ATP
Regulation of gluconeogenesis
Occurs through compartmentalization
Allosteric regulation
Phosphorylation
Changes in gene expression
When glycolysis proceeds
gluconeogenesis is inhibited
When gluconeogenesis process
Glycolysis is inhibited
Glycolysis regulation Steps
1 - Hexokinase
3 - Phosphofructokinase
10 - Pyruvate Kinase
Gluconeogenesis is regulated by
Acetyl-CoA (during conversion of pyruvate to PEP)
AMP and Fructose-2,6-6P
Glucose-6-P
(And Controlled by levels of substrate)
How many fates of pyruvate are there
5
Pyruvate reduction (lactate dehydrogenase) makes
Lactate (anaerobically)
Pyruvate carboxylation (pyruvate carboxylase) makes
Oxaloacetate