Chap 5 Flashcards
Connective tissues all consist primarily of _____________ rather than cells
Extracellular material
Connective tissue is specialized to
Physically support and connect other tissues
Maintain water required for metabolite diffusion to and from than cells
The ECM of connective tissue usually consist of both large protein fibers and non fibrous areas of unstained ____________ rich in various GAGs and water
Ground substance
An embryonic form of connective tissue which contains uniformly undifferentiated cells scattered in a gel-like matrix
Mesenchyme
The major cells of connective tissue proper, are elongated, irregularly shaped cells with oval nuclei that synthesize and secrete most components of the ECM
Fibroblasts
Are very large cells that differentiate in connective tissue called adipose tissue
Adipocytes
Shirt lived cells that differentiate in connective tissue circulating in the blood they function in ECM turnover phagocytosis of dead cells and debris and antigen presentation to lymphocytes
Macrophages
Precursors of macrophages
Monocytes
Originate from blood cell precursors and are filled with granules for the release of various vasoactive agents and other substances during inflammatory and allergic reactions
Mast cells
Are short lived cells that differentiate from B lymphocytes are specialized for the abundant secretion of specific antibodies ( immunoglobulins)
Plasma cells
Wander around various connective tissue looking for bacterial invaders and stimulating tissue repair
Leukocytes
The most important and abundant fibers are made of
Collagen
Collagen fibrils are degraded by collagenase enzymes classified as _______________ produced by macrophages
Matrix metalloproteinases (MMP)
The watery, largely unstained ECM that is more important than fibers in some types of connective tissue proper
Ground substance
Ground substance is rich in
Hydrated glycoaminoglycans, proteoglycans, and multi adhesive glycoproteins
