Chap 21- Catecholamines

Question 1

Catcholamines are:

Answer 1

DA NE Epi - NT in brain and act as hormone for adrenal medulla, heart, viscera and glands

Question 2

5HT

Answer 2

NT and GIT Fxn

Question 3

Catcholamine synthesis

Answer 3

Tyrosine –> Tyrosine hydroxylase make L-DOPA —> L-AA decarboxy make DOPAmine –> DAoxylase make N.E —> PMNT makes Epi

Question 4

Seratonin synthesis

Answer 4

Tryptophan –> Trp OHxylase makes 5HTP –> L-AA decarboxy makes 5-HT –>… Melatonin

Question 5

Histamine synthesis

Answer 5

Histidine–> Histamine decarboxylase makes Histamine

Question 6

What does L-AA decarboxylase catalyze

Answer 6

L-Dopa to DOPA

5-HTP to 5-HT

Question 7

Storage of catecholamines

Answer 7

VMAT 1 and 2, using ATP pump H+ inside the matrix granule from the cytoplasm

Question 8

Metabolism of catecholamines uses

Answer 8

MAO and COMT… that make metanephrines and VMA

Question 9

N.E and Epi .. metabolites are?

Answer 9

VMA / Sulfates and Glucoronides conjugates of MHPG

Question 10

HVA is a metabolite for?

Answer 10

DA metabolism

Question 11

5HT degradation goes to?

Answer 11

5HT —-> 5HIAA 98% with aldehyde dehydrogenase
or
5HT —> 5 HIOL 2% with aldehyde reductase and MAO

Question 12

Histamine degradation?

Answer 12

Histamine
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imidazole acetic acid or N-Imidazole acetic acid

Question 13

Neuroblastoma’s are stopping what from being made?

Answer 13

Not making Epinephrine cuz its blocking PMNT

but is making N.E