Chap-20 Bone metabolism

Question 1

What are bones made up of?

Answer 1

Mineralized ( calcium salts ) and Non-mineralized osteoid matrix

Question 2

What happens to women at menopause?

Answer 2

Progesterone decreases which causes an increase in bone resorbtion

Question 3

What classifies osteoporosis ?

Answer 3

When bone has abnormal mineralization / remodeling

Question 4

What classifies osteopenia?

Answer 4

When your x-ray results show signs of bone loss due to osteoid (matrix non collagen non mineral) being low

Question 5

What classifies osteo-porosis

Answer 5

Dec. Bone strength due to de-mineralization of bone

Question 6

What classifies Osteo-malacia /Rickets

Answer 6

Increase in Osteoid (matrix non mineral part) due to low vit.D

Question 7

What classifies paget’s disease?

Answer 7

When you have increased osteo-clast cells, resorbing the bone alot and then the formation is abnormal . Results :inc hydroxproline and ALP findings

Question 8

Osteo-genesis imperfecta is a result of?

Answer 8

Collagen problem.. non minreal osteoid problem

Question 9

Osteo-petrosis is weird because?

Answer 9

Decrease of osteo-clast function.. not resorbing bone.. get rock solid hard

Question 10

Renal osteodystrophy is?

Answer 10

Kidney not working. results in hyper-parathyroidism making pth to resorb bone .. low 25(oh)D.. because first the liver makes 25(oh)D but then the kidneys convert it to make 1,25(oh)D which makes not functioning.. and 1,25(oh)d we saw was good for ca absorbtion, and ca is good for bone

Question 11

Ostetis fibrosa

Answer 11

inc.PTh disorder.. due to a 2nd disorder which is affecting the pituitary organ

Question 12

Marker for bone formation

Answer 12

PINP / PICP/ ALP / Osteocalcin /

Question 13

Marker for bone resorption

Answer 13

ICTP , CTX, TRACP5b , Cathepsin K