Ch.9 Mucus Controlling Drug

Question 1

What is mucoactive agent and what are the indications

Answer 1

General term used for any medication or drug that has an effect on mucus secretion
Indicated for diseases with hyper secretion or poor clearance in airways

Question 2

What’s the difference between mucus, phlegm and sputum

Answer 2

Mucus: secretion from surface goblet cells and submucosal glands composed of water, proteins and glycosylated mucins

Phlegm: purulent material in airways

Sputum: phlegm that contains mouth, nose and resp tract secretions, contains bacteria and products of inflammation

Question 3

What are the 5 functions of mucus in body

Answer 3

1. Protection
2. Lubricants
3. Waterproof
4. Protect against osmotic or inflammatory changes
5. Traps microorganisms, inhibits chronic bacterial infections

Question 4

What is mucoactive therapy used for

Answer 4

1.Reduce accumulation of airway secretions
2. Improve pulmonary function and gas exchange
3. Prevent repeated infection and airway damage

Question 5

What is the trade name for dornase Alfa

Answer 5

Pulmozyme

Question 6

What is the trade name for N- Acetylcysteine ( NAC)

Answer 6

Mucomyst

Question 7

What is the rate of Mucociliary transport in the normal peripheral airway

Answer 7

1.5 mm/min

Question 8

What is the healthy mucus secretion

Answer 8

Produces 100 ml of mucus every 24 hrs
Clear, viscoelastic and sticky

Question 9

What is the mode of action for NAC: N- Acetylcysteine

Answer 9

NAC substitute sulfhydryl radicals for disulfide bonds in mucus

Question 10

Bronchospasms is most serious potential hazard associated with what

Answer 10

The use of acetylcysteine

Question 11

When administering a medication such as NAC, what should be administered prior to acetylcyseine

Answer 11

Bronchodilator

Question 12

What is the mode of action for dornase Alfa when given by aerosol

Answer 12

Dornase Alfa reduces viscosity and adhesively by breaking down DNA

Question 13

What are 6 common side effects of dornase Alfa

Answer 13

1. Voice alteration-most common hazard
2. Pharyngitis
3. Laryngitis
4. Rash
5. Chest pain
6. Conjunctivitis

Question 14

What is the name of the agent that increase volume or hydration of airway secretions

Answer 14

Expectorants

Question 15

What should patients with long term problems of secretion management do

Answer 15

They should be taught different airway clearance techniques