Ch.6 Adrenergic Bronchodialtor Flashcards
What is adrengeric bronchodilator
Agent that stimulates sympathetic nervous fibers. Allowing relaxed airway muscles
Prodrug
Drug that exhibits its pharmacologic activity when it is converted inside the body
What does adrenergic bronchodilators mimic
Epinephrine
What obstructive diseases can benefit the use of adrenergic bronchodilator
(CBABE)
Cystic fibrosis
Bronchitis
Asthma
Bronchiectasis
Emphysema
What is SABA and what is the indication
Short acting B2 agonists(SABA)
Indicated for relief of acute reversible airflow obstruction. Used as a rescue bc of quick onset
What is LABA and its indication
Long acting B2 agonists(LABA)
Indicated for maintenance therapy for asthmatics.
Longer onset
What are the indications for epinephrine (Ultra short acting agents)
Control airway bleeding.
a- adrenergic vasoconstriction
Racemic epinephrine reduces airways swelling like in: stridor, croup, epiglottitis and bronchiolitis
What drug is a ultra short acting agonist
Racemic epinephrine
Quick onset but short duration
What are some short acting B2 agonists (SABA)
Metaproterenol
Albuterol
Levalbuterol
What are some long acting agonists (LABA)
Salmeterol
Formoterol
Arformoterol
Indacaterol
Olodaterol
What are 4 ways to take albuterol
Syrup, nebulizer, MDI, oral tablets
What are catecholamines and what does it mimic
Group of similar compounds having sympathomimetic action. Mimics epinephrine
Levalbuterol is a single R- isomer of albuterol
What is epinephrine indicated for
Severe allergic reactions
Acute asthma
Cardiac stimulant
Smooth muscle relaxation most likely occurs as a result of what
An increase in intracellular cAMP
