Ch.10 Surfactant

Question 1

LaPlaces law

Answer 1

Relationship between pressure and surface tension

Question 2

Prophylactic treatment

Answer 2

Prevention of respiratory distress syndrome (RDS) in infants with both low and high weight who have immature lungs

Question 3

Surface tension

Answer 3

Attraction of molecules in a liquid air interface, pulling the surface molecules inward

Question 4

Surfactant agents aka detergents

Answer 4

Agents that reduce surface tension

Surface active agents can change surface tension at liquid air interfaces

Question 5

Laplace law in alveoli

Answer 5

Only one single air liquid interface
Equation:
Pressure = (2X surface tension)/ radius

Question 6

What will happen to the surface tension if there is a lack of pulmonary surfactant in RDS patient

Answer 6

Surface tension will increase

Question 7

What are the 3 exogenous surfactants

Answer 7

1. Prophylactic treatment: prevents RDS
2. Rescue treatment: rescue treatment for RDS
3. Newborns with evidence of immature lung development

Question 8

Define exogenous

Answer 8

Class of drugs, surfactants that prepared from outside the patients body

Question 9

What is surfactant mostly composed of

Answer 9

Phospholipids

Question 10

Where is surfactant synthesized

Answer 10

Type II alveolar cells and stored in vesicles termed lamellar bodies.

The stimulus for secretions of lamellar bodies appears to inflate the lungs

Question 11

Exogenous surfactant is also

Answer 11

Part of the surfactant recycling pool for alveolar cells

Question 12

Types of exogenous surfactants

Answer 12

Natural:
Beracrant (survanta)
Calfactant (infasurf)
Poractant Alfa (curosurf)

Synthetic:
Lucinactant (surfaxin)

Question 13

Mode of action

Answer 13

Replace and replenish deficient endogenous surfactant pool in neonatal RDS

Question 14

RDS will increase

Answer 14

Functional residual capacity FRC