Ch 12 Nonsteroidal Antiasthma Agents

Question 1

Mast cell

Answer 1

Connective tissue cells that contain heparin and histamine

Question 2

Antileukotrienes

Answer 2

Agents that block the inflammatory response in asthma

Question 3

Indications

Answer 3

Prophylactic management (control) of mild persistent asthma

Question 4

Types of antileukotrienes and monoclonal antibody

Answer 4

Antileukotrienes:
Zafirlukast, montelukast, zileuton

Monoclonal antibody:
Omalizumab

Question 5

Anti LTs can be considered as an alternative agent when ICS are not tolerated

Question 6

What is extrinsic and intrinsic

Answer 6

Extrinsic: allergy induced asthma
Intrinsic: asthma induced locally without external factors

Question 7

Mechanism of inflammation in asthma

Answer 7

Than is an inflammatory disorder resulting in chronic persistent airway inflammation and occasional wheezing caused by bronchoconstriction, mucus swelling, mucus secretions and vascular leakage

Question 8

Inflammatory response manifests as

Answer 8

1. Vascular leakage
2. Bronchoconstriction
3. Mucus secretions
4. Mucosal swelling

Question 9

Mechanism of action

Answer 9

Inhibits mast cell degranulation

Question 10

May take 2-4 weeks for improvement