Ch.7 Flashcards
3 major circulatory elements
- Pump (heart)
- Channels or tubes (blood vessels)
- A fluid medium (blood)
Blood flow must meet __ demands
Metabolic
What does heart generate to drive blood through vessels?
Pressure
6 major functions of Cardiovascular System (DRTTAI)
• Delivers O2, nutrients
• Removes CO2, other waste
• Transports hormones, other molecules
• Temperature balance and fluid regulation
• Acid–base balance
• Immune function
What side of the heart is pulmonary circulation?
Right side
What blood does the right side of the heart pump from body to lungs?
Deoxygenated
What blood does the left side of the heart pump from body to lungs?
Oxygenated
What side of the heart deals with systemic circulation?
Left side
Term for cardiac muscle
Myocardium
What are the characteristics of Left ventricle (MTLB)
-Must pump blood to entire body
-Thickest wall(hypertrophy)
-LV hypertrophied with exercise and with disease
-But exercise adaptations be disease adaptations very different
Myocardium: ___ __ artery supplies right side of heart
Coronary
Myocardium: ___ __ artery supplies left side of heart
Left(main) coronary
Coronary artery disease
Atherosclerosis
Large, long up branched multinucleated muscle cell
Skeletal muscle cells
Muscle cell that has intermittent, voluntary contractions
Skeletal muscle cells
Muscle cell with Ca2+ released from SR
Skeletal muscle cell
Small, short, branched, one nucleus cell
Myocardial cells
Muscle cell with continuous, involuntary rhythmic contractions
Myocardial cells
Muscle cell with calcium-induced calcium release
Myocardial cell
Calcium induced calcium release:
1. __ spreads along Sarcolemma down _-__
AP
T-tubules
Calcium induced calcium release:
2. __ receptors in T-tubule are __ and __
DHP (special Ca channel)
Stimulated and open
Calcium induced calcium release:
3. Extracellular ___ to enter __ but insufficient to cause __
Ca2+
Cell
Contraction
Calcium induced calcium release:
4. Instead, triggers __ receptors on SR to release __
Ryanodine (another special Ca2+ channel)
Ca2+
How many fiber types in myocardial cell?
One
Characteristics of Myocardial fiber type
-High capillary density
-High number of mitochondria
-Striated
Cardiac muscle fibers connected by regions called __ __
Intercalated discs
Intercalated discs: hold cells together
Desmosomes
Intercalated discs: rapidly conduct action potentials
Gap junctions
Cardiac muscle ability to generate own electri l signal
Spontaneous rhythmicity
TF: Spontaneous rhythmicity allows contraction with external stimulation
False
Without
Electrical impulse:
__ atrium to ___
Right
Throughout the entire heart
Starting point of spontaneous rhythmicity
Sinoatrial node (SA node)
Fastest intrinsic firing rate
About 100 bpm
Pathway of Spontaneous rhythmicity
-SA node
-AV node
-AV bundle (bundle of His)
-Purkinje fibers
SpR: initiates contraction signal and is pacemaker cell in upper RA wall
SA Node
Sinoatrial node stimulates __,__ contraction
Right Atrium
Left Atrium
SpR: delays, relays signal to ventricles in RA wall near center of heart
AV node
Atrioventricular node relays signal to __ __ after delay
Atrioventricular bundle
AV node delay allows , to contract before ,
RA, LA
RV,LV
AV bundle relays signal to , and travels along __ __
RV,LV
Interventricular septum
AV bundle divides into … and … bundle branches
Right and left
AV bundle sends signal toward … of heart
Apex
… … sends signals into RV, LV and spreads throughout entire ventricle wall
Purkinje fibers
Terminal branches of right and left bundle branches
Purkinje fibers
Purkinje fibers stimulate …,… contraction
RV, LV
Extrinsic control that decreases force of contraction and HR below intrinsic HR
Parasympathetic control
PS control:
• Intrinsic HR:
• Normal resting HR (RHR):
• Elite endurance athlete:
• Intrinsic HR: 100 beats/min
• Normal resting HR (RHR): 60 to 100 beats/min
• Elite endurance athlete: 35 beats/min
Functions of sympathetic control (IID)
– Increases force of contraction
– Increases HR above intrinsic HR
– Determines HR during physical, emotional stress
Maximum possible HR in sympathetic control
250bpm
At beginning of exercise, HR ___ due to withdrawal or PNS
Increase
All mechanical and electrical events that occur
during one heartbeat
Cardiac cycle
TF: Diastole is twice as small as systole
False
Long
1/3 of cardiac cycle time
Ventricular systole
2/3 of cardiac cycle
Ventricular diastole
Blood leftover in ventricle in first 1/3 of cardiac cycle
End-systole volume (ESV)
At end, blood in ventricle of cardiac cycle
End-diastole volume (EDV)
Volume of blood pumped in one heartbeat
Stroke volume
Equation to find stroke volume
EDV - ESV = SV
% of EDV that was SV
Ejection fraction
Equation for EF
SV/EDV = EF
Total volume of blood pumped per minute
Cardiac Output Q
Equation to find Cardiac output (Q)
Q = HR x SV
Resting cardiac output
~4.2 to 5.6 L/min
Vascular system: carries blood away from heart
Arteries
Vascular system: control blood flow, feed capillaries
Arterioles
Vascular system:site of nutrient and waste exchange
Capillaries
Vascular system: collect blood from capillaries
Venules
Vascular system: carries blood from venules back to heart
Veins
Pressure exerted by blood on arterial walls
Blood pressure
– Highest pressure in artery (during systole)
– Top number, ~110 to 120 mmHg
Systolic pressure
– Lowest pressure in artery (during diastole)
– Bottom number, ~70 to 80 mmHg
Diastolic pressure
Average pressure over entire cardiac cycle
Mean arterial pressure MAP
Equation for MAP
MAP ≈ 2/3 DPB + 1/3 SBP
Force that drives flow
Pressure
Force that opposes flow
Resistance
Flow required by all tissues
Blood flow
Calculating blood flow
Pressure / Resistance
Easiest way to change flow
Change resistance
Diverts blood to regions most in need/changes flow
Vasoconstriction (VC) or vasodilation (VD)
Known as resistance vessels that control systemic resistance
Arterioles
Site of most potent Vasoconstriction and Vasodilation
Arterioles
At rest, what is Q?
5L/min
During heavy exercise, what is Q?
25L/min
At rest, what receives 50% of Q and what receives 20%
Liver,kidneys
Skeletal muscle
Arterioles walls can respond to __ mechanisms
Local control
Ability of local tissues to constrict or dilate Arterioles that serve them
Intrinsic control
Strongest stimulus for release of local VD chemicals & builds up local metabolic products
Metabolic mechanisms
Substances secreted by vascular endothelium
Endothelial mechanisms
Local pressure changes can cause VC,VD
Myogenic mechanisms
Myogenic mechanisms:
Decrease in pressure causes:
Increase in pressure causes:
Vasodilation
Vasoconstriction
Redistribution of flow by the nervous system
Extrinsic neural control
What innervates smooth muscle in arteries and Arterioles
Sympathetic nervous system
Increase in sympathetic activity leads to __ vasoconstriction, causes blood flow to _
Increase
Decrease
Decrease in sympathetic activity leads to __ vasoconstriction, causes blood flow to _
Decrease
Increase
At rest, veins contain __ blood volume
2/3
TF: Venous reservoir can be liberated, sent back to heart and into arteries
Problem of returning blood to the heart
Upright posture makes venous return to heart more difficult
2 mechanisms that assist venous return
Muscle pump
One-way venous valves
Blood pressure is maintained by _ _
Autonomic reflexes
4 functions of Baroreceptors (SAEA)
• Sensitive to changes in
arterial pressure
• Afferent signals from
baroreceptor to brain
• Efferent signals from brain
to heart & vessels
• Adjust HR and arterial
pressure back to normal
3 major functions of Blood (TTB)
Transportation
Temperature regulation
Buffers acids from anaerobic metabolism pH balance
Blood volume of men and women
5-6 L in men
4-5 L in women
55-60% of blood volume
Plasma
40-45% of blood volume
Hematocrit
99% of hematocrit
<1%
<1%
Erythrocytes
Leukocytes
Platelets
TF: RBC has a nucleus to reproduce
False
No nucleus no reproduce
RBC is replaced regularly via
Hematopoiesis
Oxygen-transporting protein in RBC
Hemoglobin
Hemoglobin per RBC
~250 million
Molecular O2 per Hb
4
Thickness of blood due to RBC
Blood viscosity
TF: Blood is twice as viscous as water
True
If hematocrit increases, viscosity __
Increases
Plasma volume must __ as RBC _
Increase
Increase