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Pharmacology Test 4 > Ch. 45 and 46 > Flashcards

Ch. 45 and 46 Flashcards

1
Q

methotrexate (MTX)

A

Folic Acid Antagonist

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2
Q

pemetrexed

A

Folic Acid Antagonist

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3
Q

palatrexate

A

Folic Acid Antagonist

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4
Q

fludarabine

A

Purine antagonists

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5
Q

mercaptopurine

A

Purine antagonists

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6
Q

thioguanine

A

Purine antagonists

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7
Q

cladribine

A

Purine antagonists

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8
Q

pentostatin

A

Purine antagonists

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9
Q

fluorouracil

A

Pyrimidine antagonists

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10
Q

cytarabine

A

Pyrimidine antagonists

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11
Q

capecitabine

A

Pyrimidine antagonists

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12
Q

floxuridine

A

Pyrimidine antagonists

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13
Q

gemcitabine

A

Pyrimidine antagonists

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14
Q

Interferes with use of folic acid and as a result, DNA is not produced, and cell dies

A

Folic Acide Antagonism

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15
Q

Interrupts metabolic pathways of purine
nucleotides and results in interruption of synthesis of DNA and
RNA

A

Purine antagonism

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16
Q

Interrupts metabolic pathways of pyrimidine bases and results in interruption of DNA and RNA synthesis

A

Pyrimidine antagonism

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17
Q

Adverse Effects: Hair loss, myelosuppression, nausea and
vomiting. Neurologic, cardiovascular, pulmonary,
hepatobiliary, GI, genitourinary, dermatologic,
ocular, otic, and metabolic toxicity. Tumor lysis syndrome. Palmar-plantar dysesthesia (also called
hand-
foot
syndrome), Stevens-Johnson syndrome,
toxic epidermal necrolysis

A

Antimetabolites

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18
Q

Antimetabolites

A

Folic acid antagonists
Purine antagonists
Pyrimidine antagonists

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19
Q

Mitotic Inhibitors

A

Vinca alkaloids

Taxanes

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20
Q

vinblastine

A

Vinca alkaloids

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21
Q

vincristine

A

Vinca alkaloids

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22
Q

vinorelbine

A

Vinca alkaloids

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23
Q

docetaxel

A

Taxanes

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24
Q

paclitaxel

A

Taxanes

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25
Q

cabazitaxel

A

Taxanes

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26
Q

eribulin

A

Taxanes

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27
Q

Adverse Effects: Hair loss, nausea and vomiting,

myelosuppression. Liver, kidney, lung toxicities, convulsions, extravasation

A

Mitotic Inhibitors

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28
Q

topotecan

A

Topoisomerase 1 Inhibitors

Camptothecins

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29
Q

irinotecan

A

Topoisomerase 1 Inhibitors

Camptothecins

30
Q

Indications: Ovarian and colorectal cancer and small cell lung cancer

A

Topoisomerase I Inhibitors

Camptothecins

31
Q

Inhibit proper DNA function in the S phase

A

Topoisomerase I Inhibitors

Camptothecins

32
Q

Adverse effects: Bone marrow suppression (predictable, reversible,
noncumulative, manageable). GI effects (nausea, vomiting, diarrhea). Irinotecan causes cholinergic diarrhea (delayed,
occurring 2 to 10 days after dosage)

A

Topoisomerase I Inhibitors

Camptothecins

33
Q

asparaginase

A

Antineoplastic Enzyme

34
Q

pegaspargase

A

Antineoplastic Enzyme

35
Q

Used to treat acute

lymphocytic leukemia

A

asparaginase

36
Q 
MOA: Work by preventing cancer cells from
reproducing. Alter the chemical structure of the cells’
deoxyribonucleic acid (DNA). Bifunctional or polyfunctional
A

Alkylating Drugs

37
Q

cisplatin

A

Alkylating Drugs

38
Q

cyclophosphamide

A

Alkylating Drugs

39
Q

mechlorethamine

A

Alkylating Drugs

40
Q

carmustine

A

Alkylating Drugs

41
Q 
Used in combination with other drugs to treat various
types of cancer, such as:

Recurrent ovarian cancer

Brain tumors

Lymphomas

Leukemias

Breast cancer

Bladder cancer
A

Alkylating Drugs

42
Q

daunorubicin

A

Anthracycline antibiotics

43
Q

doxorubicin

A

Anthracycline antibiotics

44
Q

epirubicin

A

Anthracycline antibiotics

45
Q

idarubicin

A

Anthracycline antibiotics

46
Q

valrubicin

A

Anthracycline antibiotics

47
Q

R/o heart failure when taking _____

A

daunorubicin

48
Q

R/o acute left ventricular failure when taking ______.

A

doxorubicin

49
Q

R/o pulmonary fibrosis and pneumonitis when taking _____.

A

bleomycin

50
Q

bevacizumab

A

Angiogenesis inhibitor

51
Q

Blocks blood
supply to the growing tumor. Used to treat metastatic colon cancer, rectal
cancer in combination with 5-fluorouracil, non–
small cell lung cancer, and malignant glioblastoma. Nephrotoxic

A

bevacizumab

52
Q

Used to treat squamous cell carcinoma and some

leukemias

A

hydroxyurea

53
Q

Many adverse effects: edema, drowsiness,
headache, rash, hyperuricemia, nausea, vomiting,
dysuria, myelosuppression, nephrotoxicity,
pulmonary fibrosis

A

hydroxyurea

54
Q

Used to treat chronic myeloid leukemia (CML). Works by inhibiting this enzyme that is active in
the CML process

A

imatinib

55
Q

Adrenal cytotoxic drug. Used specifically for inoperable adrenal corticoid
carcinoma.
Oral form only

A

mitotane

56
Q

anastrozole

A

Aromatase inhibitors

57
Q

aminoglutethimide

A

Aromatase inhibitors

58
Q

tamoxifen

A

Selective estrogen receptor modulators

59
Q

toremifene

A

Selective estrogen receptor modulators

60
Q

megestrol

A

Progestins

61
Q

medroxyprogesterone

A

Progestins

62
Q

fluoxymesterone

A

Androgen

63
Q

testolactone

A

Androgens

64
Q

fulvestrant

A

Estrogen receptor antagonist

65
Q

bicalutamide

A

Antiandrogens

66
Q

flutamide

A

Antiandrogens

67
Q

nilutamide

A

Antiandrogens

68
Q

leuprolide

A

Gonadotropin-releasing hormone agonists

69
Q

goserelin

A

Gonadotropin-releasing hormone agonists

70
Q

estramustine

A

Antineoplastic horomone

71
Q

Used to treat esophageal and bronchial tumors in

combination with laser light therapy

A

Porfimer sodium

72
Q

Leaking of an antineoplastic drug into
surrounding tissues during IV administration. Can result in permanent damage to nerves,
tendons, muscles, loss of limbs. Skin grafting or amputations may be
necessary

A

Extravasation

Pharmacology Test 4 (10 decks)

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