Ch 24- Part 2 Alteration in Cardiovascular Function Flashcards
Coronary Artery Disease is usually caused by ________ (1) (plaque that build up diminishing blood supply to cardiac muscle cells)
It results in myocardial ______ (2) and infarction deprives heart muscle of blood-borne O2 (______ (3)) and nutrients and impair heart pumping ability.
- Atherosclerosis
- ischemia
- hypoxic
Persistent ischemia causes what syndrome which include myocardial infarction?
Acute Coronary Sydrome
T or F: Myocardial cells remain alive when the person has CAD and also functioning properly.
FALSE; Myocardial cells remain alive BUT are not FUNCTIONING PROPERLY.
Infarction potentially triggers ____ attack
heart
What is cardiac infarction?
obstruction of blood supply causing irreversible myocardial damage
What is the link between ab lipoproteins levels and CAD?
dyslipidemia
What are the 2 types of lipoproteins?
High density lipoproteins (HDL)
Low density lipoproteins (LDL)
LDL is responsible for DELIVERY of cholesterol to _____ (1) while HDL is responsible for delivery of excess cholesterol back to the ______ (2).
- tissues
- liver
T or F: High intake of cholesterol and saturated fats leads to decreased LDL.
FALSE; LEADS TO ELEVATED LDL
Excessive levels of LDL causes LDL migration into vessel wall which initiates _______ (reduced blood supply to myocardial cells)
atherosclerosis.
T or F: HDL plays a role in endothelial repair and increases thrombosis.
FALSE; DECREASES THROMBOSIS
T or F: Elevated levels of HDL has not proven to prevent cardiovascular diseases
TRUE
Hypertension is responsible for __-___ fold increase in CAD risk
2-3
What is the cause of hypertension that leads to CAD? (2 pts)
endothelial injury – atherosclerosis and myocardial hypertrophy (increase heart O2 demand)
What is myocardial hypertrophy?
increases heart O2 demand
Cigarette smoking is a ___ ____ generation
free radical
When we are smoking , what chemical stimulates catecholamines (epi/nor-epi)?
nicotine
Nicotine stimulates catecholamines which _____ (1) HR and vasoconstriction which increases _____ (2)
increases (1) & B.P (2)
CAD risk _____(1) with heavy smoking & _____(2) when smoking stopped.
Smoking is associated with _____ (3) LDL and ______(4) HDL
- increases
- decreases
- increased
- decreased
Abdominal obesity = strongest risk of CAD/ related to ____ (1) and decreased (LDL or HDL)_____ (2)
inflammation (1) & HDL (2)
T or F: Sedentary lifestyle not only increases risk of obesity but on its own increases risk of CAD
TRUE
What is atherogenic diet.
diet that promotes formation of fatty plagues in arteries
What type of diet is an atherogenic diet?
Western-style diet
What is the recommended diet?
Mediterranean diet
Which blood test can detect very low levels of C-reactive protein (CRP)?
hs-CRP test
T or F: Elevated serum hs-CRP is correlated to decreased CAD risk
FALSE; Correlated to increased CAD risk
What does hs-CRP test used for?
determine heart disease risk & stroke without know heart disease
What is CRP (C-reactive protein)?
protein sythesized in liver in response to increase in inflammation of body.
What is the hs-CRP value for high risk?
greater than 3 mg/L
What is the hs-CRP value for low risk?
less than 1 mg/L
What is the hs-CRP value for average risk?
1-3 mg/L
What are the 2 hormones produced from adipose cells?
leptin and adinopectin
What type of hormones are leptin and adinopectin?
Adipokines
Obesity = increased ____(1; hormone) & decreased _____ (2; hormone)
leptin (1) & adinopectin (2)
Adinopectin protects vascualr endothelium and is ____- ______
anti-inflammatory
How does myocardial ischemia develop?
blood-borne O2 is insufficient to meet myocardial metabolic demands.
What is the common cause of myocardial ischemia?
atherosclerosis in coronary circulation
Atherosclerosis in coronary circulation = ____(1) ruptures = ____(2) formation = occlusion = myocardial _____ (3)
- plaque
- thrombus
- ischemia
How long do myocardial cells become ischemic when occlusion occurs?
within 10 sec
During myocardial ischemia, there is a shift toward anaerobic, thus there is accumulation of _____ (1) acid – there is then a decreased rate of ____ (2) re-phoshorylation.
- lactic
- ATP