Cervix Pathology

Question 1

Sx’s = benign exophytic growths that cause irregular vaginal spotting/bleeding

Answer 1

Endocervical polyps

Question 2

Morph: loose fibromyxomatous stroma covered by mucus-secreting glands

Answer 2

Endocervical polyps

Question 3

What is the greatest risk factor for development of cervical neoplasias

Answer 3

HPV (16, 18)

Question 4

What age group is most affected by cervical neoplasias?

Answer 4

20-40 yo

Question 5

What does E6 do to cause neoplasia?

Answer 5

Binds p53 preventing apoptosis

Question 6

What does E7 do to cause neoplasia?

Answer 6

Binds RB causing increased cell proliferation

Question 7

Which type of CIN has a high level of viral replication and mild alterations in growth of host cells?

Answer 7

LSIL

Question 8

Which type of CIN has increased proliferation, decreased epithelial maturation, and lower rates of viral replication?

Answer 8

HSIL

Question 9

HSIL will express which markers?

Answer 9

Ki-67 and p16

Question 10

Morph: koilocytic atypia with variations in nuclear size and shape and perinuclear vacuoles (halos)

Answer 10

CIN (SIN)

Question 11

Which type of cancer is the most common type of cervical carcinoma?

Answer 11

SCC

Question 12

What is the average age of Dx for SCC of the cervix?

Answer 12

45 yo