Breast Carcinoma Pathology Flashcards
Which type of breast carcinoma has an increased risk with age?
ER+
What are the major genes associated with Familial breast carcinoma?
BRCA1/2, TP53, CHEK2
Which gene is associated with single gene familial breast cancers?
BRCA1/2
Which gene is associated with an increased risk of ovarian carcinoma?
BRCA1
Which gene is associated with male breast cancer?
BRCA2
Which mutations are more likely to be ER+?
BRCA2
Which mutations are associated with increased risk of prostatic and pancreatic carcinoma?
BRCA1/2
Which mutations are associated with Li Fraumeni syndrome?
TP53
What is the most common cancer subtype of BRCA2 mutations?
ER+, HER2-
Which mutations are ER+, HER2- cancers associated with?
PIK3CA
What is the precursor lesion for ER+, HER2- cancers?
Flat epithelial atypia and atpical ductal hyperplasia
What is the most common mutation associated with HER2+ cancers?
TP53
What is the most common type of mutation associated with ER-, HER2- cancers?
BRCA1
African American women have an increased frequency of which subtype of breast cancer?
ER-, HER2-
Def: malignant clonal proliferation of epithelial cells limited to ducts and lobules by the basement membrane with preserved myoepithelial cells
CIS
Morph: clustered or linear and branching areas of calcification defined by tumor cells with pleomorphic high-grade nuclei and areas of central necrosis
Comedo CIS
Morph: cribriform pattern (cookie cutter) with central necrosis and no high-grade nuclei
Non-Comedo CIS
Morph: malignant cells extend from DCIS within the ductal system and into the nipple skin without crossing the basement membrane
Paget disease