Cerebrospinal Fluid Flashcards

1
Q

what color is CSF

A

colorless

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2
Q

where is CSF produced

A

the 4 ventricles of the brain

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3
Q

what secretes CFS

A

choroid plexus

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4
Q

function of CSF

A
  • supplies nutrient to nervous tissue
  • removes metabolic waste
  • cushions brain and spinal cord
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5
Q

what does the central nervous system consist of

A

brain

spinal cord

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6
Q

what is the outer layer of the central nervous system

A

dura mater

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7
Q

what is the middle layer of the central nervous system

A

arachnoid mater

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8
Q

what is the inner layer of the central nervous system

A

pia mater

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9
Q

what layers do CSF flow through

A

arachnoid mater and Pia mater

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10
Q

what are the protective coverings of the brain

A

bone
meninges
fluid

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11
Q

def? dura mater, arachnoid mater, pia mater

A

meninges

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12
Q

how is CSF made

A

hydrostatic pressure and active secretion

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13
Q

how many mL of CSF do adults have

A

85-150 mL

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14
Q

how many mL of CSF do neonates have

A

10-60 mL

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15
Q

what blood-brain barrier condition is blockage of drainage of CSF

A

hydrocephalus

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16
Q

treatment of hydrocephalus

A

sugary

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17
Q

how many tubes are used for CSF collection

A

3

sometimes 4

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18
Q

what kind of testing is prioritized if there is only a little bit of CSF

A

micro and cellular testing

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19
Q

if there is even blood distribution in all 3 tubes of CSF what does that indicate

A

hemorrhage

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20
Q

if there is uneven blood distribution in the 3 tubes of CSF what does that indicate

A

traumatic tap

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21
Q

true or false: CSF testing is not STAT

A

F

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22
Q

cause of xanthochromic (pink to orange) CSF sample

A

bilirubin

breakdown of hemoglobin

23
Q

cause of clotted CSF sample

A

protein

fibrinogen

24
Q

cause of pellicle (thick mmb/film) CSF sample

A

protein

clotting factors

25
Q

what method is used to count CSF cells

A

Neubauer hemocytometer counting chamber

26
Q

how many WBC is normal per microliter in CSF sample

A

0-5

27
Q

what are the most common WBCs seen in CSF fluid

A

lymphocytes and monocytes

28
Q

normal ratio of lymphocytes to monocytes in CSF (adults)

A

70:30

29
Q

def? increased amounts of normal cells

A

pleocytosis

30
Q

pleocytosis helps determining the cause of what

A

meningitis

31
Q

if you see lots of neutrophils in CSF what kind of meningitis is this

A

bacterial

32
Q
if you see lots of lymphocytes in CSF what kind of \_\_\_ viral 
tubercular
fungal
parasitic
syphilis is this
A

meningitis

33
Q

if blast forms in CSF what is the clinical significance

A

acute leukemia

34
Q

if lymphoma cells are in CSF what is the clinical significance

A

disseminated lymphomas

35
Q

if plasma cells are in CSF what is the clinical significance

A

multiple sclerosis

36
Q

if eosinophils are in CSF what is the clinical significance

A

parasites, allergic

37
Q

if ependymal choroidal and spindle-shaped cells are in CSF what is the clinical significance

A

diagnostic procedures

38
Q

if malignant cells are in CSF what is the clinical significance

A

metastatic carcinomas

39
Q

what do neutrophil often contain in CSF

A

phagocytized bacteria

40
Q

who is more likely to have a traumatic tap

A

children

41
Q

in a traumatic tap how many WBC are there for every 1000 RBC

A

1 to 2

42
Q

what do arachnoid, ependymal, and choroid plexus cells mistaken for

A

malignant cells

43
Q

what stain is used for bacteria and fungi

A

gram stain

44
Q

what stain is used for cryptococcus neoformans

A

india ink

45
Q

what stain is used for tuberculosis meningitis

A

acid-fast stain

46
Q

what stain is used for ameba naegleria fowleri

A

wright stain

47
Q

normal amount of protein in CSF

A

15-45 mg/dL

48
Q

what protein is monitored for multiple sclerosis

A

myelin basic protein

49
Q

formula for CSF/serum albumin index

A

albumin CSF (mg/dL)/ albumin serum (g/dL)

50
Q

what is the normal amount of CSF/serum albumin index

A

less than 9

51
Q

in protein electrophoresis what is the 2nd band

A

tau protein

52
Q

what kind of salt increases in both bacterial, fungal, or tuberculous infections

A

lactate

53
Q

what a.a increases when ammonia levels increase

A

glutamine

54
Q

what a.a is associated with loss of consciencness, coma, or liver disorders

A

glutamine