Cephalosporins Flashcards
T/F each succeeding generation is more effective against g negative bacteria and broader spectrum of activity
T, 4th gen has broadest spectrum
Cephalosporins not active against
L. monocytogenes
Enterococci
Cefazolin
1st gen
Cephalothin
1
Cephalexin
1
Cephradine
1
Cefadroxil
1
Cefaclor
2
Cefamandole
2
Cefonicid
2
Cefuroxime
2
Cefprozil
2
Loracarbef
2
Ceforanide
2
Cefixime
3
Moxalactam
3
Ceftriaxone
3
Cefotaxime
3
Cefepime
4
Gram positive cocci
Pneumococci
Streptococci
Staphylococci
Cross allergenicity more common compared to other generations
1st
The only first gen cephalosporin still in use
Cefazolin
2nd gen extension, organisms?
Klebsiella H. influenza B. fragilis M. catarrhalis N. gonorrhea N. meningitides
2nd gen cephalosporin that can cross the BBB
Cefuroxime
3rd gen with useful activity against P. aeruginosa
Ceftazidime
Cefoperazone
Used as empirical therapy of sepsis of unknown cause in immunocompromised and immunocompetent patients
3rd gen cephalosporins
Reduced effects against staph but same activity against strep
Ceftriaxone
Iv/im cns and genitourinary infections
Bone and joint infections
Skin and soft tissue infections
Mild community acquired respiratory infections
Ceftriaxone
Adverse effect: biliary sludge
Ceftriaxone
Has longest half life among 3rd gen
Ceftriaxone
Goo activity against P. aeruginosa
Cefepime
LRTs
UTI
Skin and soft tissue infections
Intra abdominal infections
Cefepime
Most stable against beta lactamases produced by gram negative bacteria
Cefepime
Pref for nosocomial infections and those caused by enterobacteriaceae
Cefepime
Ceftriaxone administration
IM
IV
Cefepime admin
IV
Cefuroxime admin
IV
Oral
Cefazolin admin
IM
IV
Alternative for antistaph penicillin Surgical and endocarditis prophylaxis Bone and joint infections Pharyngitis Community acquired UTIs
Cefazolin
Kidney failure
Hemolytic anemia are effects of
Cefazolin
Community acq uti and rti
Bone and joint infections
Skin and soft tissue infections
Cefuroxime
