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Ther 201 3rd Exam > Antibacterials 7 > Flashcards

Antibacterials 7 Flashcards

0
Q

50s inhibitor, interferes with formation of initiation complexes, aminoacyl translocation

A

Clindamycin

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1
Q

Binding site for clindamycin identical with

A

Chloramphenicol and macrolides

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2
Q

Penetrates well into abscesses

A

Clindamycin

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3
Q

Percent of protein bound clindamycin

A

90%

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4
Q

Alternative for staph and strep for those allergic to beta lactams, alternative to cotrimoxazole for jiroveci and toxoplasmosis

A

Clindamycin

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5
Q

Recommended rather than erythromycin for endocarditis prophylaxis for those undergoing certain dental procedures

A

Clindamycin

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6
Q

Combined with clindamycin for jiroveci pneumonia

A

Primaquine

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7
Q

Important quinolones are…

A

Synthetic fluorinated derivatives of nalidixic acid

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8
Q

Quinolones moa

A

Blocks topo ii and topo iv

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9
Q

Prevents relaxation of positively coiled DNA

A

DNA gyrase/ Topo II

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10
Q

Interferes with separation of replicated chromosomal DNA into respective daughter cells during cell division

A

Topo IV

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11
Q

Quinolone, 1st gen

A

Nalidixic acid

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12
Q

Quinolone with narrowest spectrum

A

Nalidixic acid

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13
Q

2nd gen quinolones

A

Ciprofloxacin

Ofloxacin

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14
Q

Best for pseudomonas

A

Ciprofloxacin

Ofloxacin

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15
Q

3rd gen quinolones

A

Levofloxacin
Moxifloxacin
Gatilfloxacin

16
Q

Quinolone, problems with blood sugar of diabetic patients

A

Gatilfloxacin

17
Q

Hepatotoxic quinolone

A

Trovafloxacin

18
Q

Effective in UTIs even if caused by mdr bacteria like pseudomonas

A

Fluoroquinolones except moxifloxacin

19
Q

Drug of choice for treatment and prophylaxis of anthrax

A

Ciprofloxacin

20
Q

Effective for gonococcal inf, chlamydial urethritis, cervicitis

A

Ciprofloxacin and levofloxacin

21
Q

Severe GIT inf, UTI, MDR typhoid, severe RTIs due to gram negs, osteomyelitis/septicemia

A

Ciprofloxacin

22
Q

Most specific fluoroquinolone against P aeruginosa

A

Ciprofloxacin

23
Q

Vancomycin moa

A

Inhibits cell wall synthesis

24
Q

Vancomycin difference from beta lactams

A

Binds to d al d ala not an analogue

25
Q

Vancomycin is synergistic with

A

Streptomycin

Gentamicin

26
Q

First line therapy for C difficile colitis

A

Metronidazole

27
Q

Poorly absorbed in the gi tract but used for treatment of colitis due to C difficle, not first line

A

Vancomycin

28
Q

MRSA

Plus combined with cefotaxime, ceftriaxone, or rifampin for meningitis caused by penicillin resistant pneumococcus

A

Vancomycin

29
Q

Vancomycin for gram pos and neg?

A

NO! Gram positive only

30
Q

Vancomycin adverse effects

A

Red man syndrome
Ototoxicity
Nephrotoxicity

31
Q

Vancomycin can kill all Gram pos except

A

Flavobacterium

Ther 201 3rd Exam (16 decks)

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