Antibacterials 6

Question 0

50S inhibitors

Answer 0

Chloramphenicol
Macrolides
Clindamycin

Question 1

100 % oral bioavailability, 7% renally excreted

Answer 1

Chloramphenicol

Question 2

Binds reversibly to 50s subunit, inhibits peptide bond formation, bacteriostatic broad spectrum, active against Rickettsiae not chlamydiae

Answer 2

Chloramphenicol

Question 3

Cloramphenicol inactivation

Answer 3

Glucuronidation

Reduction to aryl amines

Question 4

Oral formulation for bacterial meningitis for penicillin sensitive patients

Answer 4

Chloramphenicol

Question 5

Topical for eye infection, typhus, Rocky Mountain spotted fever

Answer 5

Chloramphenicol

Question 6

Adverse effect

Gray baby syndrome

Answer 6

Chloramphenicol

Question 7

50S inhibitor that crosses the placenta and is present in breastmilk and CSF

Answer 7

Chloramphenicol

Question 8

Macrocyclic lactone ring

Answer 8

Macrolides

Question 9

Romycins

Answer 9

Macrolides

Question 10

Blocks polypeptide exit tunnel

Answer 10

Erythromycin, macrolides

Question 11

Special formulation of macrolides?

Answer 11

Enteric coating bec destroyed by stomach acid

Question 12

50s inhibitor, lost in feces and bile

Answer 12

Erythromycin

Question 13

Drug of choice in corynebacterial infections

Diptheria, sepsis, erythrasma

Answer 13

Erythromycin

Question 14

Macrolide more active against M avium complex

Answer 14

Clarithromycin

Question 15

Macrolide active against M avium, T gondii, H inf, Chlamydia, but less active against strep, staph

Answer 15

Azithromycin

Question 16

Macrolide that does not inhibit cyp450

Answer 16

Azithromycin