Antibacterials 3 Flashcards
Wide spectrum good activity
Gram neg rods
Gram pos organisms
Anaerobes
Imipinem
Most broad spectrum so is used for polymicrobial infections
Carbapenems
Imipenem most commonly administered with inhibitor of renal dehydropeptidase
Cilastatin
Carbapenem with longest halflife
Ertapenem
Carbapenems no effect on
MRSA E faecium C difficile B cepacia S maltophilia
Carbapenems not active against
L monocytogenes
Enterococcus
Excessive levels of imipenem in patients with renal failure may lead to
Seizures
Carbapenems Cross allergenicity with
Penicillin
Beta lactamase inhibitors
Clavulanic acid
Sulbactam
Tazobactam
B lactamase inhibitors have their own antibacterial activity, t or f
False
Tazobactam especially acts on which B lactamases
SHV-1
TEM
Diarrhea
Hepatitis, jaundice
Hemolytic anemia
Tazobactam
Tazobactam used in combination with
Piperacillin