Antineoplastics 2

Question 0

Methotrexate cell cycle phase?

Answer 0

S phase, self limiting

Question 1

Specific carrier mediated, glutamyl residues impt for duaration of action

Answer 1

Methotrexate

Question 2

Methotrexate antidote

Answer 2

Leucovorin

Question 3

Bone marrow deppression
Oral and GI ulcerations
Pulmonary infiltrates and fibrosis

Answer 3

Methotrexate

Question 4

Fluorine sub analog or uracil

Answer 4

5FU

Question 5

5fu 5fdump blocks action of thymidilate synthetase, 5 utp incorporated into rna, not phase specific

Answer 5

5 fluorouracil

Question 6

S specific antimetabolite, inhibits dna pol

Answer 6

Cytarabine

Question 7

Ribose is replaced with ______, cytarabine

Answer 7

Arabinose

Question 8

Inhibits adenylosuccinate synthetase and inosinate

Answer 8

Mercaptopurine

Question 9

Bone marrow depression

Hyperuricemia

Answer 9

Mercaptopurine

Question 10

Bone marrow depression

Sudden respiratory distress with high doses

Answer 10

Cytarabine

Question 11

Bone marrow depression
Oral GI ulcerations
Severe diarrhea

Answer 11

5 fluorouracil

Question 12

AML

Answer 12

Thioguanine

Cytarabine

Question 13

ALL

Answer 13

Methotrexate (children)

Mercaptopurine

Question 14

CML

Answer 14

Cytarabine

Mercaptopurine

Question 15

Adenocarcinomas of GI tract, breast CA, premalignant skin hyperkeratosis, superficial bcca

Answer 15

Fluorouracil

Question 16

Antimetabolites

Answer 16

Methotrexate 
Fluorouracil
Cytarabine 
Mercaptopurine 
Thioguanine