Antibacterials 4

Question 0

Which natural pen has oral bioavailability?

Answer 0

Pen vk

Question 1

Natural penicillins

Answer 1

Pen g

Pen vk

Question 2

For 
Bacterial meningitis
Syphilis
Pneumonia
Leptospirosis

Answer 2

Pen G

Question 3

Only for
Pneumonia (S. pneumonia) and leptospirosis
Can’t treat syphilis, meningitis or H. Influenzae infections

Answer 3

Pen VK

Question 4

Penicillase resistant pens

Answer 4

Oxacillin

Cloxacillin

Question 5

Anti-staphylococcal pens

Answer 5

Oxacillin

Cloxacillin

Question 6

Oxacillin and cloxacillin no activity on

Answer 6

Gram neg,
anaerobes,
enterococci

Question 7

Which one has inc GI absorption and reduce hepatic clearance, oxacillin or cloxacillin?

Answer 7

Cloxacillin

Question 8

Purely oral antistaph pen

Answer 8

Cloxacillin

Question 9

Aminopens

Answer 9

Amoxicillin

Ampicillin

Question 10

Aminopens ampicillin and amoxicillin with activity on

Answer 10

Gram positives L monocytogenes, S viridans
Gram negatives E coli, N. meningitides, P mirabilis, Shigella, Salmonella
Anaerobic Clostridium Peptococcus

Question 11

Usually administered with clavulanic acid

Answer 11

Amoxicillin

Question 12

Most commonly used aminopen, oral

Answer 12

Amoxicillin

Question 13

Semisynthetic pen alpha benzyl derivative of pen G, well distributed in body and CSF, broad spectrum antibiotic

Answer 13

Ampicillin

Question 14

For 
Otitis media
LRTi
Acute bacterial sinusitis 
Pyelonephritis

Answer 14

Amoxicillin

Question 15

Basic structure of penicillin

Answer 15

Thiazolidine ring attached to beta lactam ring

Question 16

Repository forms of penicillin

Answer 16

Benzathine and procaine

Question 17

Moa penicillins

Answer 17

Structural analog of D-ala-D-ala, binds to active site of PBPs

Question 18

Reaction inhibited by penicillins

Answer 18

Transpeptidation reaction

Question 19

Resistance against penicillins

Answer 19

Inactivation by beta lactamase
Mod of PBPs
Impaired penetration esp in gram negs, thick cell wall
Efflux

Question 20

Absorption of penicillins and food

Answer 20

Impaired, take 1 h before or 2 h after a meal

Question 21

Painful when done with pen g

Answer 21

IM

Question 22

Can raise bloodlevels of penicillins

Answer 22

Probenecid

Question 23

Nafcillin clearance

Answer 23

Biliary excretion

Question 24

Partial biliary excretion

Answer 24

Oxacillin
Cloxacillin
Dicloxacillin

Question 25

Penicillin main excretion

Answer 25

Renal
10% glomerular filtration
90% tubular secretion