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Ther 201 3rd Exam > Antiparasitics 1 > Flashcards

Antiparasitics 1 Flashcards

0
Q

Amoebiasis

A

Diloxonide
Paramomycin
Metronidazole

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1
Q

Giardia

A

Metronidazole

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2
Q

Metronidazole moa

A

N group accepts e- from ferrodoxin of amoebic parasite
Reductive bioactivation produces cytotoxic products
React with protein and DNA

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3
Q

For severe amoebiasis, hepatic amoebic abscess, extraintestinal amoebiasis

A

Metronidazole

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4
Q

Can metronidazole penetrate the bbb?

A

Yes! Can be used to treat B fragilis brain abscess

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5
Q

First line drug for C difficle colitis

A

Metronidazole

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6
Q

Only aerobic bacteria that metronidazole can affect

A

Helicobacter pylori

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7
Q

Dry mouth with metallic taste, pancreatitis, ataxia, encephalopathy, seizures, dizziness, vertigo, disulfiram like reaction

A

Metronidazole

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8
Q

Metronidazole kind of drug

A

Nitromidazole

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9
Q

Diloxinide furoate can affect which stage of amoeba?

A

Before encystment

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10
Q

Entamoeba histolytica cyst, not active against trophozoites

A

Diloxonide

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11
Q

Malaria caused by 4 species of Plasmodium

A

Falciparum
Vivax
Ovale
Malariae

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12
Q

Most common plasmodium in the phil

A

Falciparum

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13
Q

2nd most common plasmodium in the phil

A

Vivax

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14
Q

Current P falciparum resistance profile in the phil

A

Artemether
Chloroquine
Fansidar

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15
Q

Most number of cases of malaria in the Philippines

A

Palawan

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16
Q

3 stages of Plasmodium cycle

A

Exo-erythrocytic
Erythrocytic
Sporogonic

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17
Q

Gut of mosquito

A

Sporogonic

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18
Q

Liver of human

A

Exo-erythrocytic

19
Q

First line malaria treatment Philippines

A

Coartem

20
Q

Only tissue schizontocide

A

Primaquine

21
Q

Treatment regimen for uncomplicated vivax malaria

A

Day 0 and 1 CQ 150 mg, 10mg/kg/day, 4 tab/day

Day 2 CQ 150mg, 5mg/kg/day, 2 tab

Day 3 to 17 Primaquine, 15mg, 0.5mg/kg/d, 1 tab

22
Q

Primaquine contraindicated in

A

Severe g6pd

23
Q

Malaria prophylaxis drugs

A

Mefloquine

Doxycycline

24
Q

Antibacterial 2nd line drugs for malaria

A

Tetracycline
Doxycycline
Clindamycin

25
Q

Coartem

A

Artemether-lumefantrime

26
Q

Very rapidly acting blood schizonticide against all malaria parasites, no effect on liver stage

A

Artemether

27
Q

Artemether contraindicated for pregnant women?

A

NO!

28
Q

Artemether metabolite

A

Dihydroartemisinin

29
Q

Artemesia in the Philippines

A

Vulgaris

30
Q

Endoperoxide containing natural antimalarials from sweet wormwood

A

Artemisinin

31
Q

Lumefantrine, when taken with food

A

Improved absorption

32
Q

Minor arrhythmia and long qt

A

Coartem

33
Q

Quinine effect adverse

A

Cinchonism

Git distress, headache, vertigo, blurred vision, tinnitus

34
Q

Quinine moa

A

Complexes with dsDNA preventing separation

35
Q

Therapeutic dose may cause hypoglycemia by insulin release, especially in severe infections in pregnant patients

A

Quinine

36
Q

Not usually used unless sure that it is vivax

A

Chloroquine

37
Q

Prevents biocrystallization of parasite heme into hemozoin causing heme buildup and parasite lysis

A

Chloroquine

38
Q

Alopecia, hair bleaching, hypotension, widened qrs, abnormal t waves

A

Chloroquine

39
Q

Antifolate drugs, malaria

A

Pyrimethamine

Sulfadoxime

40
Q

Fansidar

A

Fixed combination
Sulfadoxime and
Pyrimethamine

41
Q

May cause folic acid deficiency

A

Pyrimethamine

42
Q

Eradicates exoerythrocytic and gametocytic forms

A

Primaquine

43
Q

With longer tissue stage, falciparum or vivax?

A

Vivax

44
Q

How many days of primaquine?

A

Falciparum 1

Vivax 14

Ther 201 3rd Exam (16 decks)

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