Antineoplastics 4

Question 0

Catalyzes hydrolysis of L-asparagine to asp acid and ammonia

Answer 0

Asparaginase

Question 1

Enzymes and enzyme inhibitors

Answer 1

Asparaginase

Etoposide

Question 2

Hepatotox

CNS depression

Answer 2

Asparaginase

Question 3

Most sensitive cells to asparaginase

Answer 3

Lymphoblasts in ALL

Question 4

Antimitotic, delays transit of cells through s phase, arrest in late s or early g2

Answer 4

Etoposide

Question 5

Bone marrow tox, podophyllin derivative

Answer 5

Etoposide

Question 6

Testicular cancer, hodgkins, lung cancer

Answer 6

Etoposide

Question 7

Stimulates dna topoisomerase ii to cleave dna

Answer 7

Etoposide

Question 8

Monoclonal antibodies

Answer 8

Trastuzumab
Rituximab
Bevacizumab
Cetuximab

Question 9

Downreg of HER2 receptor, dec angiogenesis

Answer 9

Trastuzumab

Question 10

Against CD20 antigen

Answer 10

Rituximab

Question 11

Antiangigenesis, attaches to and stops vegf, usually used with 5FU

Answer 11

Bevacizumab

Question 12

Targets EGF, used with irinotecan

Answer 12

Cetuximab

Question 13

Colorectal cancer

Answer 13

Cetuximab

Question 14

Metastatic colorectal cancer

Answer 14

Bevacizumab

Question 15

B cell non hodgkin lymphoma, post transplant lymphoma, CLL

Answer 15

Rituximab

Question 16

Breast cancer

Answer 16

Trastuzumab

Question 17

Outcome of chemotherapy (5)

Answer 17

Tumor size
Tumor heterogeneity 
Organs involved and location of tumor
Pharmacologic factors
Host factors