Cells and Tissues: Epithelial Tissue Flashcards
key functions of epithelial tissues
Selective barriers
secretory
protection
Tight junctions
Claudins and occlaudins attach adjacent cells, maintain cell polarity, make cells electrically tight i.e. skin
Adherns Junctions
‘Belt desmosomes’, have a plaque layer joining actin (microfilament) to cadherins, catenins link the two, prevent from tension forces i.e. contractions
Desmosome
Have plaque, keratin spans from one side desmosome to another across cytoplasm to maintain shape and stick cells together, cadherin links intercellular space, i.e. muscle cells
Gap junctions
Direct channel between cells to pass messages, 6 connexIn’s form a connexOn, 2 gap juncs form a hemi channel, allow ~1kDa molecules i.e. cardiac tissue
junctional complex
tight, adherens, desmosome
microfilaments
ACTIN, bundles below membrane and cytoplasm,, strength, alter cell shape, tie cells together, muscle contraction
Intermediate Filaments
KERATIN, strength, move materials through cytoplasm
Hemidesmosome
Connect to the basement membrane, Intergrin links to laminin in the basement membrane and to Keratin intermediate filament
Basal Lamina
secreted by epithelial cells, contains collagen, laminin, other proteoglycans, glycoproteins etc is a TOP
reticular lamina
Produced by cells of underlying connective tissue fibroblasts, contains fiberous proteins fibroectin, collagen etc is a BOTTOM
Epithelia contain nerves but not blood vessels making them?
Avascular
How do epithelia recieve nutrients and remove waste
diffusion from vessels in connective tissue
4 functions of basement membrane
supports overlying epithelium, surface for cells migrate during growth and wound healing, a physical barrier, filtrates substances in the kidney
where is Covering and lining epithelia
form outer covering of skin and organs, inner lining of blood vessels, ducts and body cavities
where is Glandular epithelia
secretory portion of glands
two major types of epithelia
Epithelia, glands
two kinds of glands (crine)
Exocrine (into ducts that go to surface - sweat, salivary, oil, wax glands, pancreas) is stratified cuboidal, Endocrine (into blood that go to surface - pituitary, pineal, thyroid)
Simple arrangement pros and places
Single layer for secretion, absorbtion, filtration - avioli
Stratified arrangement pros and places
2+ layers for protection i.e skin
Pseudostratified arrangement pros and places
Appears to have multiple layers position of nuclei, not all cells reach apical surface, all cells with basement membrane, secretion i.e upper bronchi
Squamous shape pros and places
flat and thin, diffusion - lungs
Cuboidal shape pros and places
about as tall as they are wide, secretion and absorption - digestion
Columnar shape pros and places
More tall than wide, secretion, absorption
Transitional shape pros and places
Stratified epithelium, cells change shape from cuboidal-flat for organ shape, allow stretch - bladder
simple squamous epithelium specialized subtypes
Mesothelium - lines pericardial, pleural, peritoneal cavities
Endothelium - lines inside of heart, blood and lymphatic cells
simple cuboidal epithelium features
secretion and absorption, distance between nuclei is approx. hight of epithelium - pancreas ducts, kidney tubules
simple columnar epithelium subtypes
Non-ciliated and ciliated
Non-ciliated simple columnar epithelium
single layer with microvilli apical surface, have goblet cells, secretion and lubrication - gut stomach to anus, gall bladder
Ciliated simple columnar epithelium (move materials)
single layer, goblet cells, cilia wave move mucus + foreign objects - some bronchioles, uterine tubes
Stratified Squamous subtypes
Stratified Squamous Epithelium (non-keratinized),
Stratified Squamous Epithelium (keratinized)
Stratified Squamous Epithelium (non-keratinized)
Protect from abrasion and microbes, require gland secretion - mouth, throat, tongue
Stratified Squamous Epithelium (keratinized)
Keratinized dead surface cells on top of living cells, act as scaffolding to have trauma - skin
Psuedo-stratified Columnar Epithelium subtypes
Pseudostratified Columnar Epithelium (ciliated and non-ciliated)
Pseudostratified Columnar Epithelium (ciliated)
secrete mucus (goblet cells) and move it - most of upper airways
Pseudostratified Columnar Epithelium (non-ciliated)
absorption and protection, Larger ducts of glands, epididymis, part of male urethra
Glandular epithelia
single cell or group secrete into ducts, a surface or blood
3 characteristics to describe structure of multicellular glands
- structure of duct
- structure of secretory area
- relationship between the two