cell signalling and cell membrane Flashcards
balls like structures of phospholipids
micelles
sheet like structures of phospholipids
bilayers
fluidity in fluid mosaic model
both phospholipids and proteins can move
mosaic in fluid mosaic model
pattern produced by the scattered proteins molecules when cell membrane is viewed from above
what to double c-c bonds to do fluidity
unsaturated tails make the membrane more fluid as fatty acid tails are bent and fit together more loosely
what happens to fluidity as temp decreases
it decreases as there is less ke and phospholipids move less and pack together
cholesterol
acts as fluidity buffer, stops pl packing together when low temps
hydrophobic regions help prevent ions and polar molecules form passing through
5 things the gp+gl+pr can be for
receptor molecules
cell to cell recognition
transport proteins
enzymes
cytoskeleton
channel proteins
water filled pores
allow charged substances(ion) to diffuse and water
gated
only down conc gradient
carrier proteins
flip between 2 shapes
transport up and down conc gradient
cell signalling
molecular mechanisms by which cells detect and respond to external stimuli including communication between cells
step of cell signalling
- stimulus causes cell to secret a ligand
2.ligand is transported to target cell
3.ligand binds to cell surface receptor on the target cell - transduction- ligand causes change of shape of receptor
5.receptor spans membrane so message is passed to inside of cell
6.response
autocrine signalling
receptors on releasing cells
paracrine signalling
receptors on adjacent cell
endocrine signalling
signals have to travel through blood
ligand
a biological molecules which binds to another molecule like a cell surface membrane receptor during cell signalling
transduction
process of converting a signal from one method of transmission to another
4 factors affecting diffusion
nature of molecules
surface area
temp
steepness of conc gradient
what to channel p carry
only ions
aquaporins
type of channel protein for water as when water diffuses normally it is slow
what to carrier p carry
glucose, amino acids, nucleotides, sugar
what are channel p
hydrophilic pores in cell membrane
only down conc gradient
what are carrier p
integral proteins up and down conc gradient
water potential
tendency of water to move from one place to another
wp depends on
conc of sol
pressure applied
endocytosis
the bulk movement of liquids or solids into a cell by the unfolding cell surface membrane to form vesicles containing the substance
requires app
exocytosis
the bulk movement of liquids or solids out of a cell by the fusion of vesicles containing the substance with the cell surface membrane
active process requires atp
phagocytosis
bulk uptake of solid material. phagocytes specialise in this
bulk uptake of liquid
pinocytosis/micropinicytosis
3 stages of cell signalling
reception transduction and response
what is transduction
the receptor changes shape triggering the signal to be passed along multistep pathway. the signal is converted to a message that can be passed on
signalling amplification
many secondary messengers in response to one activated receptor (signalling cascade)