cell division (mitosis) Flashcards

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1
Q

what does mitosis produce?

A

2 genetically identical daughter cells

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2
Q

why is mitosis necessary?

A

for the growth of multicellular organisms, and repairing damaged tissues

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3
Q

what are the stages of the cell cycle?

A

mitosis
gap phase 1
synthesis
gap phase 2

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4
Q

what happens in gap phase 1?

A

cell grows and new organelles/proteins are made

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5
Q

what happens in synthesis?

A

cell replicates its DNA, so it is ready to divide by mitosis

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6
Q

what happens in gap phase 2?

A

cell keeps growing, proteins needed for cell division are made

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7
Q

what happens in interphase?

A

the cell carries normal functions
DNA unravelled and replicated
organelles are replicated
ATP content increased

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8
Q

what happens in prophase?

A
chromosomes condense 
get shorter and fatter 
centrioles move to opposite ends of the cell forming spindle fibres 
nuclear envelope breaks down 
chromosomes lie free in the cytoplasm
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9
Q

what happens in metaphase?

A

chromosomes line up along the middle of the cell

are attached to the spindle by their centromere

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10
Q

what happens in anaphase?

A

centromeres divide
sister chromatids are separated
spindle fibres contract
chromatids are pulled to opposite poles of the cell

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11
Q

what happens in telophase?

A

chromatids reach opposite poles
uncoil- become long and thin
nuclear envelope forms around chromosomes to make two nuclei
cytokinesis finishes
results in two genetically identical daughter cells

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12
Q

what is cancer?

A

uncontrolled cell growth which leads to tumour formation

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13
Q

how is cancer caused?

A
mutation in a gene involved in the cell cycle
cell cycle no longer controlled 
apoptosis not completed 
uncontrolled cell growth 
tumour formation
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14
Q

what is a benign tumour?

A

doesn’t spread

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15
Q

what is a malignant tumour?

A

spreads

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16
Q

how does chemotherapy work?

A

targets G1
prevents synthesis of enzymes for DNA replication
cell cannot enter synthesis
disrupts the cell cycle so the cell kills itself

17
Q

how does radiotherapy work?

A

targets S phase
damage DNA
when DNA is checked for damaged, damage is detected so the cell will kill itself
prevents further tumour growth

18
Q

what is the equation for mitotic index?

A

number of cells with visible chromosomes/total number of cells observed