Celiac And Alt Therapies Flashcards
Define food intolerance.
Lacks enzyme to digest or more nutrients than enzyme. Not immune mediated
Lactose intolerance or FODMAPs
Define food sensitivity.
Variety of reactions when eating the food.
Usually not immune mediated response to nutrient.
No permanent damage.
Gluten sensitivity
Define food allergy.
Specific IgE mediated immune response rx to protein
Respond min-hrs after exposure
Usually 1st yr of life
Milk allergy wheat allergy
What does the body specifically react to from the cereals? What does it cause?
Prolamins-storage protein
Causes chronic inflammation, flat villi (Villous atrophy), malabsorption
What genes are specific to CD?
HLA-DQ2 and HLA-DQ8
Classic S/S of CD?
N/V, abd cramping, gas, bloating, chronic diarrhea to constipation, steatorrhea, dehydration, folate deficiency anemia, wt loss, dermatitis herpetiformis (lesions on GI tract and skin)
Specific cereal triggers and the proteins in them?
Wheat (gliadin)
Rye (secalin)
Barley (hordein)
What makes up the prolamin of wheat (storage protein)?
Gliadin and glutenin.
Steps of cellular and humoral response with gluten exposure?
High cellular TH1 makes INF gamma
Lymphocytes into epith makes humoral response then IgA, IgA, IgM
Gliadin upregulates zonulin to raise permeability
Proteins into circulation
What is zonulin? What does it regulate?
Intestinal permeability regulator. It is expressed after gliadin binds CXCR3 on outside of cell. Upregulation leads to leaky gut.
What 5 conditions being present mean to screen for CD?
Infertility Osteoporosis Lupus DM1 Thyroid diseases
Why is osteoporosis common with CD?
Less Ca and Vit D b/c think lactose intolerant
Thyroid probs- Ca comes out of bones
Prednisone- use to manage pain
No exercise or wt bearing activity -tired
Malabsorption fat so SOAP form with Ca Zn Mg
What is DH?
Dermatitis herpetiformis
85% people with this have CD. Only 10% people with CD have DH.
Watery itchy blisters. IgA deposited under top layer of skin.
How is CD usually Dx?
Detect serum IgA anti-tTG antibodies (sensitive to CD)
Gold standard: intestinal mucosal biopsy (need to be eating gluten still!)
Good names to know with CD?
A. Fasano (zonulin)
Michelle Pitzack
High risk groups for developing CD?
Down's UC Asthma Eczema Fibromyalgia Autoimmune (T1DM, thyroid, lupus, RA)
What is silent CD?
Not clinically harming until secondary effects (T1DM, Lupus, RA, osteoporosis, CA)
Just patchy small intestine involvement