Cartilage and Bone Flashcards
What is the common embryonic origin of cartilage and bone?
Mesenchyme
What is the order of cell development which forms bone?
- Mesenchyme
- Osteoblast
- Osteocyte
- Bone
What is the order of cell development which forms cartilage?
- Mesenchyme
- Chondroblast
- Chondrocyte
- Cartilage
Name 4 features of cartilage
- Strong but slightly flexible
- Withstands compression forces
- Major role in endochondral ossification
- Avascular
How do chondroblasts change into chondrocytes?
Chondroblasts secrete ECM and become trapped inside to become chondrocytes
How do chondrocytes exist in the matrix?
Enclosed in lacunae
What are the 3 types of cartilage?
- Hyaline
- Elastic
- Fibrocartilage
Name 3 places hyaline cartilage is found
- Articular surfaces of bone
- Trachea + Bronchus
- Costal cartilage
Name 2 places elastic cartilage is found
- Pinna of external ear
2. Epiglottis
Name 3 places fibrocartilage is found
- Tendon insertions
- Pubic symphysis
- Intervertebral discs
What colour does hyaline cartilage stain in H&E?
Mottled
What comprises the matrix of hyaline cartilage?
Type 2 collagen fibres embedded in a gel of proteoglycans and structural glycoproteins
Why can hyaline cartilage work as such an effective shock absorber?
High water content bound to GAGs
What does GAG stand for?
Glycosaminoglycan
What is the main difference between elastic and hyaline cartilage?
Elastic cartilage contains elastic fibres
What is the main difference between elastic and hyaline cartilage and fibrocartilage?
Fibrocartilage lacks a perichondrium