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PASS SOUTH CLUES > Cardiology Pharm (Lipid Lowering Agents) > Flashcards

Cardiology Pharm (Lipid Lowering Agents) Flashcards

1
Q

What are the HMG-CoA reductase inhibitors? (5)

A 
Lovastatin
Pravastatin
Simvastatin
Atorvastatin
Rosuvastatin
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2
Q

What are the indications for HMG-CoA reductase inhibitors? (3)

A

Strong decrease LDL
Decrease triglycerides
Increase HDL

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3
Q

What are the adverse effects of HMG-CoA reductase inhibitors?

A

Hepatotoxicity (increase LFT’s) rhabdomyolysis

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4
Q

What is the mechanism of action of Niacin? (2)

A

Inhibits lipolysis in adipose tissue

Reduces hepatic VLDL secretion into circulation

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5
Q

What are the indications for Niacin? (2)

A

Decrease LDL and triglycerides

Strong increase HDL

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6
Q

What are the adverse effects of Niacin? (3)

A

Red flushed face which is decreased by aspirin
Hyperglycemia
Hyperuricemia

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7
Q

What are the Bile Acid Resins? (3)

A

Cholestyramine
Colestipol
Colesevelam

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8
Q

What is the mechanism of action of Bile Acid Resins? (2)

A

Prevent intestinal reabsorption of Bile acids

Liver must use cholesterol to make more

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9
Q

What are the indications for Bile Acid Resins? (2)

A

Slightly increase HDL and triglycerides

Decrease LDL

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10
Q

What are the adverse effects of Bile Acid Resins? (3)

A

Tastes bad and causes GI discomfort
Decrease absorption of fat soluble vitamins
Cholesterol gallstones

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11
Q

What are the Cholesterol Absorption Blockers?

A

Ezetimibe

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12
Q

What is the mechanism of action of Ezetimibe? (2)

A

Prevent cholesterol reabsorption at small intestine

Brush border

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13
Q

What are the indications for Ezetimibe?

A

Decrease LDL

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14
Q

What are the adverse effects of Ezetimibe?

A

Rare increase LFT’s

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15
Q

What are the Fibrates? (4)

A

Gemfibrozil
Clofibrate
Bezafibrate
Fenofibrate

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16
Q

What is the mechanism of action of Fibrates?

A

Upregulate LPL -> increase Triglyceride clearance

17
Q

What are the indications for Fibrates? (3)

A

Strong decrease of triglycerides
Slight decrease of LDL
Slight increase in HDL

18
Q

What are the adverse effects of Fibrates? (3)

A

Myositis
Hepatotoxicity (increase LFT’s)
Cholesterol gallstones

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