2nd messenger Receptors

Question 1

a1

Answer 1

Gq Sympathetic noradronergic (VESSELS):
↑vascular SM contraction
mydriasis
↑intestinal, bladder, prostate muscle contraction

Question 2

a2

Answer 2

Gi Sympathetic noradronergic (HOLD BACK CATs):
↓sympathetic outflow
↓insulin release
↓catecholamine release

Question 3

B1

Answer 3

Gs Sympathetic noradronergic (INCREASE HEART):
↑HR, contractility, renin release
↑lipolysis

Question 4

B2

Answer 4

Gs Sympathetic noradronergic (LUNGS):
bronchodilation - radial muscles
vasodilation, ↑HR, contractility
↑lipolysis, insulin release
↓uterine tone

Question 5

M1

Answer 5

Gq Parasympathetic (SHOULDERS UP, BELT DOWN):
CNS
enteric nervous system

Question 6

M2

Answer 6

Gi Parasympathetic (DECREASE HEART):
↓HR, ↓atrial contractility

Question 7

M3

Answer 7

Gq Parasympathetic (GLANDS):
↑gut peristalsis, bladder contraction
↑exocrine gland secretion
bronchoconstriction
miosis, accommodation

Question 8

D1

Answer 8

Gs Dopaminergic (KIDNEY):
relaxes renal vascular smooth muscle

Question 9

D2

Answer 9

Gi Dopaminergic (BRAIN):
decrease transmitter release

Question 10

H1

Answer 10

Gq Histaminergic (ALLERGIES):
↑mucus production, contraction of bronchioles, pruritis, pain

Question 11

H2

Answer 11

Gs Histaminergic (GI):
↑gastric acid secretion

Question 12

V1

Answer 12

Gq Vasopressin (VESSELS):
↑vascular SM contraction

Question 13

V2

Answer 13

Gs Vasopressin (KIDNEY):
↑aquaporin H2O permeability and resorption @CD

Question 14

Gs receptors

Answer 14

receptor → ↑Adenylyl cyclase → (ATP → ↑cAMP) → ↑Protein kinase A
(B1, B2, D1, H2, V2)

Question 15

Gi receptors

Answer 15

receptor → ↓Adenylyl cyclase → (ATP → ↓cAMP) → ↓Protein kinase A
(‘too MAD 2 inhibit’ = all 2s)

Question 16

Gq receptors

Answer 16

receptor → ↑PhospholipaseC → (lipids → ↑PIP2) → ↑IP3 + ↑DAG → ↑Ca2+in + ↑Protein kinase C
(HaV 1 M&M)

Question 17

N

Answer 17

Nicotinic cholinoceptor

Question 18

u

Answer 18

mu