2nd messenger Receptors Flashcards
drill types and locations of receptors
1
Q
a1
A
Gq Sympathetic noradronergic (VESSELS):
↑vascular SM contraction
mydriasis
↑intestinal, bladder, prostate muscle contraction
2
Q
a2
A
Gi Sympathetic noradronergic (HOLD BACK CATs):
↓sympathetic outflow
↓insulin release
↓catecholamine release
3
Q
B1
A
Gs Sympathetic noradronergic (INCREASE HEART):
↑HR, contractility, renin release
↑lipolysis
4
Q
B2
A
Gs Sympathetic noradronergic (LUNGS): bronchodilation - radial muscles vasodilation, ↑HR, contractility ↑lipolysis, insulin release ↓uterine tone
5
Q
M1
A
Gq Parasympathetic (SHOULDERS UP, BELT DOWN):
CNS
enteric nervous system
6
Q
M2
A
Gi Parasympathetic (DECREASE HEART): ↓HR, ↓atrial contractility
7
Q
M3
A
Gq Parasympathetic (GLANDS): ↑gut peristalsis, bladder contraction ↑exocrine gland secretion bronchoconstriction miosis, accommodation
8
Q
D1
A
Gs Dopaminergic (KIDNEY): relaxes renal vascular smooth muscle
9
Q
D2
A
Gi Dopaminergic (BRAIN): decrease transmitter release
10
Q
H1
A
Gq Histaminergic (ALLERGIES): ↑mucus production, contraction of bronchioles, pruritis, pain
11
Q
H2
A
Gs Histaminergic (GI): ↑gastric acid secretion
12
Q
V1
A
Gq Vasopressin (VESSELS): ↑vascular SM contraction
13
Q
V2
A
Gs Vasopressin (KIDNEY): ↑aquaporin H2O permeability and resorption @CD
14
Q
Gs receptors
A
receptor → ↑Adenylyl cyclase → (ATP → ↑cAMP) → ↑Protein kinase A
(B1, B2, D1, H2, V2)
15
Q
Gi receptors
A
receptor → ↓Adenylyl cyclase → (ATP → ↓cAMP) → ↓Protein kinase A
(‘too MAD 2 inhibit’ = all 2s)
