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PASS SOUTH CLUES > Cardiology Pharm (Antiarrhythmics) > Flashcards

Cardiology Pharm (Antiarrhythmics) Flashcards

1
Q

What are the Class IA antiarrhythmics? (3)

A

Quinidine
Procainamide
Disopyramide

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2
Q

What is the mechanism of action of the Class IA antiarrhythmics?

A

Na+ channel blocker

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3
Q

What are the indications for the Class IA antiarrhythmics? (4)

A

Increase AP duration
Increase Effective Refractory Period (ERP)
Increase QT interval
Affect reentrant and ectopic SVT and Ventricular Tachy

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4
Q

What are the adverse effects of the Class IA antiarrhythmics? (2)

A

Quinidine: Cinchonism
Procainamide: Torsades de Pointes

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5
Q

What are the Class IB antiarrhythmics? (3)

A

Lidocaine
Mexiletine
Tocainide

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6
Q

What is the mechanism of action of the Class IB antiarrhythmics? (3)

A

Decrease AP duration
Acute Ventricular Arrhythmias
Local anesthesia

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7
Q

What are the adverse effects of the Class IB antiarrhythmics? (3)

A

CNS stimulation and depression
Cardiovascular depression
Hyperkalemia increases toxicity

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8
Q

What are the Class IC antiarrhythmics? (3)

A

Flecainide
Encainide
Propafenone

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9
Q

What is the mechanism of action of the Class IC antiarrhythmics?

A

Na+ channel blocker

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10
Q

What are the indications for the Class IC antiarrhythmics? (2)

A

Ventricular Tachycardia progressing to Ventricular Fib

Last Resort

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11
Q

What are the adverse effects of the Class IC antiarrhythmics? (2)

A

Prolongs refractory period in AV node

Hyperkalemia increases toxicity

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12
Q

What are the K+ channel blockers? (4)

A

Sotalol
Ibutilide
Bretylium
Amiodarone

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13
Q

What is the mechanism of action of the K+ channel blockers? (3)

A

Increase AP duration
Increase Effective Refractory Period (ERP)
Increase QT interval

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14
Q

What are the indications for the K+ channel blockers? (5)

A

Wolff-Parkinson-White

Torsades de Pointes, Pulmonary Fibrosis, Hepatotoxicity
Hypo/Hyperthyroidism

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15
Q

What are the Ca2+ channel blockers? (2)

A

Verapamil

Diltiazem

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16
Q

What is the mechanism of action of the Ca2+ channel blockers? (2)

A

Decreases conduction velocity of the AV node

Increases EERP and PR interval

17
Q

What are the indications for the Ca2+ channel blockers?

A

SVT/ prevent nodal arrhythmias

18
Q

What are the adverse effects of the Ca2+ channel blockers? (5)

A 
Flushing
Edema
Constipation
CHF
AV block

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