Cardiology Pharm (Cardiac Glycosides)

Question 1

What is the mechanism of action of Digoxin? (3)

Answer 1

Direct inhibition of Na+/K+ ATPase leads to indirect
Inhibition of Na+/Ca2+ exchanger -> positive inotropy
Stimulates vagus nerve

Question 2

What are the indications for Digoxin? (2)

Answer 2

CHF (increase contractility)
A Fib (decrease conduction at the AV node and depression of the SA node)

Question 3

What are the adverse effects of Digoxin? (4)

Answer 3

Cholinergic
ECG: increase PR, decrease QT
Worsened by renal failure
Quinidine displaces Digoxin from tissue binding sites

Question 4

What is the mechanism of action of Nesiritide? (2)

Answer 4

Recombinant B-NP

Increase in cGMP and vasodilation

Question 5

What are the indications for Nesiritide?

Answer 5

Acute decompensated heart failure

Question 6

What are the adverse effects of Nesiritide?

Answer 6

Hypotension