Cardio Lec 5 Flashcards
During re-polarization you have to put __ away
calcium
How is calcium put away?
active transporter puts it back in SR
Muscle cannot relax until __ & why
end of plateau phase bc you need to put calcium away
Digitalis
used to treat severe heart failure
What does digitalis do
inhibits Na/K pump -> Na accumulates in cell
The more calcium
the more forceful the contraction bc you get more actin & myosin interactions
What happens when Na accumulates in the cell
Na/K EXCHANGER will pump Na out in exchng for Ca in -> heart contracts more forcefully (pos. ionotropic agents)
Positive ionotropic agent
drugs that cause a more forceful contraction
Tetanization
when muscle stimulated so rapidly that theres no time for it to relax STAYS CONTRACTED -> muscle fatigues quickly bc using available enegy
Is tetanization favorable for cardiac muscle?
no -> CO would be 0 bc heart would stay contracted & wouldnt be able to fill AND bc it would fatigue
How does the heart not tetanize?
by having long absolute refractory periods heart wouldn’t respond to another stimulus bc wouldn’t be able to fire another action potential
How does tetanization occur?
by firing repetitive action potentials
T/F: Perkinje fibers have to spread impulses through ventricular myocytes very RAPIDLY, but if left to pace heart on their own fire action potentials infrequently -> lower hr
T
Signal gets delayed at the __, because
AV node bc it allows ventricles time to fill
EKG records
electrical activity of heart (ALL action potentials of ALL cells of heart)
T/F: EKG measures valve tension
F
P wave represents
atrial depolarization -> atrial contraction
Is it possible to have another contraction come in prior to relaxation occurring?
no
When is absolute refractory period over?
after heart has relaxed so you cant tetanize as a result
QRS com
ventricular depolarization -> ventricular contraction & atrial repolarization
T wave
ventricular repolarization -> relaxation
What do the waves show?
electrical activity