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Psych 345A > Cannabis > Flashcards

Cannabis Flashcards

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1
Q

What is the generic name?

A

Dronabinol

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2
Q

what are the synthetic alternatives?

A

K2 or spice

emerged from scientific research meant to study effects of the receptors

exhibits stimulant and hallucinogenic properties

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3
Q

what are Phytocannabinoids? What are the characteristics?

A

Tetrahydrocannabinoid

metabpolites are active
11-hydroxy THC is formed in the liver from THC- most active metabolite

Highly lipid soluble however molecule is protein bound

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4
Q

What is 11-hydroxy THC and where is it formed?

A

is formed in the liver from THC- most active metabolite

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5
Q

Cannabinoids Potency?

A

Hashish is more potent than marijuana

2-6x more

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6
Q

What are problems with modern strains of weed?

A

Show more variability and higher concentration

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7
Q

What is the dose dependent effects of weed?

A

Light headed, tingling -> euphoric, exhilarated -> calm relaxed

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8
Q

What is the intake characteristics for inhalation of cannabinoids?

A

1min - 2/4 hrs

only 50% of the THC is released into smoke

  • time held in lungs affects absorption
  • 20% is absorbed
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9
Q

What is a contact high?

A

Second hand inhalation can result in psychoactive levels

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10
Q

What is the intake characteristics of ingestion of cannabinoids?

A

First pass metabolism deactivates by 50%

metabolites still psychoactive but release lesser extent

requires 3x more to achieve comparable high to inhalation

“gatekeeper mechanism”

highly lipid soluble

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11
Q

cannibinoids use what type of agonism?

A

partial agonism

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12
Q

Partial agonism effects the body in what way?

A

Endocannabinoid system

Neurotransmitters: anadamide, 2-AG

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13
Q

What is the CB1 receptor involved in?

A

psychology

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14
Q

What is the CB2 receptor involved in?

A

protection

manufactured in hippocampus
related to glial cells

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15
Q

What happens if there is a lack of 2-AG?

A

correlated with bowel cancer

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16
Q

What is the Behavioural effects of THC?

A

Motor coordination and reaction time

and Amotivational syndrom

17
Q

What are the characteristics of motor coordination and reaction time in low and high dosages?

A

Low dose: increase in motor activity and decrease in coordination

High dose: decrease motor activity and decrease reaction time

18
Q

What are the characteristics of Amotivational syndrome?

A

Persistent lack of motivation to engage in productive activities

-no real evidence for this

19
Q

What is the short term memory impairment at low and high dosages?

A

Low:
memory deficits with no attention impairment

High dosage: memory, reasoning and attention impairment

20
Q

Cognitive effects of THC on decelerated time?

why does the happen?

A

it is associated with the “stoned” phase in which the perception of time is slowed down.

reduction in blood flow to cerebellum
causes Temporal disintegration

21
Q

What is Temporal disintegration?

A

alteration in perceptions associated with time

Flight of ideas -spontaneous seemingly random ideas

subjectively reported as racing thoughts, through maybe related to vigilance and time perception

cognitive threshold impairment

22
Q

What are the Long term effects of Cannabinoids?

A

“gateway” or stepping stone theory

weed will lead to illicit drug use

the alternative is correlated vulnerabilities that drug use is accounted for by the users characteristics

23
Q

What are the long term effects of cannabinoids when compared to non-users in Verbal fluency and divided attention (perseverating)?

A

No difference was found when compared heavy users to former heavy users, light users and non users

24
Q

Cannabinoid Tolerance?

A

in a study there was an increase from 1 j a day to 19 a day over 21 days (lol)

25
Q

Cannabinoid withdrawal?

A

Weed 5 participants demonstrated irritability, uncooperativnenss, resistance, and hostility, appetite suppression, insomnia

26
Q

Cannabinoid Toxicity?

delta 9 THC

A

Delta 9 THC low toxicity no reported OD

27
Q

Cannabinoid Toxicity? Dronabinol?

A

30 mg/KG

lethargy, decreased motor coordination, slurred speech, postural hypotension

Psych 345A (15 decks)

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