amphetamine

Question 1

Amphetamine is a what?

Answer 1

Alkaloid

Question 2

what do amphetamines act as?

Answer 2

Sympathomimetic
bronchial dilation
increased BP
treat asthma

Question 3

Synthesized amphetamine’s street name is?

Answer 3

Speed

Question 4

How is it administered?

Answer 4

Oral

Question 5

What is an example?

Answer 5

Benzedrine

Question 6

What does Benzedrine do?

Answer 6

Decongestant, appetite suppressant

Question 7

Treatment for what?

Answer 7

ADHD

Question 8

Methylated amphetamine is also called what?

what is its advantage?

Answer 8

Crack, ice, crystal meth

quicker passage across BBB

Question 9

What is the mechanism of action of amphetamine?

Answer 9

Leaky vesicles, reuptake inhibitor -Norepinephrine (x9), dopamine, serotonin negligible

Inhibit monoamine oxidase (MAO)
increase dopamine
acts like anti-depressant

Question 10

Dependance on amphetamine

Answer 10

Psychological (craving)

depression, anxiety, sleep disturbances

Question 11

Amphetamine Tolerance

Answer 11

Tachyphylaxis (few hours)

Question 12

Amphetamine

Withdrawal

Answer 12

Lethargy, dysthymia (depressed mood)

Question 13

What the the 3 symptoms of amphetamine psychosis

Answer 13

1) Chronic use/ toxicity: panic, paranoia
Formication: perceiving bugs crawling under skin
compulsive/repetitive behaviours:
trivial aspects of life
2) wild/bizarre delusions, hallucinations
dopamine release in limbic system similar to schizophrenia
3) tweaking
irritability, paranoia, violent behaviour
interaction with sleep deprivation