C/7. Agents Against Hepatitis Viruses Flashcards

1
Q

Drugs need to know in this topic

A
IFN-alpha
Entecavir
Tenofovir
Paritaprevir
Grazoprevir
Sofosbuvir
Dasabuvir
Velpatasvir
Elbasvir
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2
Q

Non-sepecific (traditional agents)

A

IFN-alpha
Entecavir
Tenofovir

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3
Q

IFN-alpha

A

Acts via JAK-STAT pathway
Selective antiviral activity via host cell defece mechanism

Hepatitis B chronic infection
Hepatitic C infection in combination with ribavirin
Others (Kaposi sarcoma, hairy cell leukemia, Malignant melanoma etc)

IM, SC injection
Renal elimination

Flu-like symptoms
GI symptoms
Alopecia
BM suppression
Ototoxicity
Thyroid dysfunction
CNS effects
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4
Q

Entecavir

A

Guanosine analogue
Inhibits HBV DNA polymerase

Hepatitis B infection

Oral
Renal elimination

Headache, dizzness
Fatigue
Nausea

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5
Q

Tenofovir

A

Nucleotide analogue

Tx of hepatitis B infection

Oral

Nephrotoxicity

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6
Q

Direct-acting antiviral (DAA)

A

disrupt viral replication and infection

All agents are orally-active
All pts are suitable for DAA therapy

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7
Q

Paritaprevir

Grazoprevir

A

Non-structural proteins 3/4A(NS3/4A) protease inhibitors(PI’s)

Common SEs
Fatigue
GI distress
Headaches
Anemia
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8
Q

Sofosbuvir

A

NS5B nucleoside polymerase inhibitors (NPI’s)

Common SEs
Fatigue
GI distress
Headaches
Anemia
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9
Q

Dasabuvir

A

NS5B non-nuceloside polymerase inhibitors (NNPI’s)

Common SEs
Fatigue
GI distress
Headaches
Anemia
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10
Q

Velpatasvir

Elbasvir

A

NS5A inhibitors

Common SEs
Fatigue
GI distress
Headaches
Anemia
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