C/7. Agents Against Hepatitis Viruses Flashcards
Drugs need to know in this topic
IFN-alpha Entecavir Tenofovir Paritaprevir Grazoprevir Sofosbuvir Dasabuvir Velpatasvir Elbasvir
Non-sepecific (traditional agents)
IFN-alpha
Entecavir
Tenofovir
IFN-alpha
Acts via JAK-STAT pathway
Selective antiviral activity via host cell defece mechanism
Hepatitis B chronic infection
Hepatitic C infection in combination with ribavirin
Others (Kaposi sarcoma, hairy cell leukemia, Malignant melanoma etc)
IM, SC injection
Renal elimination
Flu-like symptoms GI symptoms Alopecia BM suppression Ototoxicity Thyroid dysfunction CNS effects
Entecavir
Guanosine analogue
Inhibits HBV DNA polymerase
Hepatitis B infection
Oral
Renal elimination
Headache, dizzness
Fatigue
Nausea
Tenofovir
Nucleotide analogue
Tx of hepatitis B infection
Oral
Nephrotoxicity
Direct-acting antiviral (DAA)
disrupt viral replication and infection
All agents are orally-active
All pts are suitable for DAA therapy
Paritaprevir
Grazoprevir
Non-structural proteins 3/4A(NS3/4A) protease inhibitors(PI’s)
Common SEs Fatigue GI distress Headaches Anemia
Sofosbuvir
NS5B nucleoside polymerase inhibitors (NPI’s)
Common SEs Fatigue GI distress Headaches Anemia
Dasabuvir
NS5B non-nuceloside polymerase inhibitors (NNPI’s)
Common SEs Fatigue GI distress Headaches Anemia
Velpatasvir
Elbasvir
NS5A inhibitors
Common SEs Fatigue GI distress Headaches Anemia