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PHARMACOLOGY SEMMELWEIS > B/26. Semisynthetic and synthetic opiates > Flashcards

B/26. Semisynthetic and synthetic opiates Flashcards

1
Q

Drugs need to know in this topic

A

Strong agonist

Hydromorphone

Fentanyl

Meperidine

Oxycodone

Methadone

Weak agonist

Tramadol

Loperamide

Diphenoxylate

Dihydrocodeine

Dextromethorphan

Mixed activity

Buprenorphine

Nalbuphine

Opioid antagonists

Naloxone

Methyl
Naltrexone

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2
Q

Hydromorphone

A

Strong agonist Semi-synthetic 1. Analgesic use (post-operative pain, chronic pain syndromes)

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3
Q

Fentanyl

A

Strong agonist synthetic 1. Analgesic use (post-operative pain, chronic pain syndromes); transdermal/sublingual 2. Anesthesia

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4
Q

Tramadol

A

Weak agonist

Synthetic

  1. Analgesic use (neuropathic pain, dentistry)

*NE and 5-HT reuptake inhibition (serotonin syndrome)

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5
Q

Meperidine

A

Strong agonist

Synthetic

  1. Analgesic use (emergency care, pre-operative)
    *Anti-muscarinic effect; metabolite has serotonergic activity (serotonin syndrome)
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6
Q

Oxycodone

A

Strong agonist

Semi-synthetic

  1. Analgesic use (post-operative pain, chronic pain syndromes) *Potential drug of abuse
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7
Q

Loperamide

A

Weak agonist

Synthetic

  1. Anti-diarrheal agents
    *Loperamide has no CNS effects
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8
Q

Diphenoxylate

A

Weak agonist

Synthetic

  1. Anti-diarrheal agents
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9
Q

Dihydrocodeine

A

Weak agonist

Semi-synthetic

  1. Antitussive
  2. Analgesic effect in combination with NSAID’s or acetaminophen
    *NE and 5-HT reuptake inhibition (dextromethorphan)
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10
Q

Dextromethorphan

A

Weak agonist

Synthetic

  1. Antitussive
  2. Analgesic effect in combination with NSAID’s or acetaminophen
    *NE and 5-HT reuptake inhibition (dextromethorphan)
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11
Q

Methadone

A

Strong agonist

Synthetic

  1. Management of opioid withdrawal syndrome
  2. Maintenance programs for addicts (heroin, morphine)
    *Long serum T1/2
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12
Q

Buprenorphine

A

Mixed activity

Semi-synthetic

  1. Management of opioid withdrawal syndrome
  2. Maintenance programs for addicts (heroin, morphine)
    *Long serum T1/2
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13
Q

Nalbuphine

A

Mixed activity

Semi-synthetic

  1. Spinal anesthesia
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14
Q

Naloxone

A

Strong antagonist

Semi-synthetic

  1. Management of acute opioid overdose (IV administration only)

*T1/2 1-2 h’

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15
Q

Methyl Naltrexone

A

Strong antagonist Synthetic

  1. Management of opioid withdrawal syndrome (oral administration)
  2. Management of alcohol withdrawal syndrome
    *Long serum T1/2 up to 48 h’
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PHARMACOLOGY SEMMELWEIS (54 decks)

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