C/17. Glycopeptides. Fusidans. Lipopeptides. Bacitracin. Mupirocin. Pharmacotherapy Of Skin And Soft Tissue Infections. Flashcards

1
Q

Drugs need to know in this topic

A

Vancomycin
Teicoplanin
Oritavancin

Daptomycin

Bacitracin

Fusidic acid
Mupirocin

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2
Q

Glycopeptide antibiotics

MOA

A

Binding at the D-ala-D-ala terinal of the nascent peptidoglycans pentapeptide side chains
->inhibits the transglycoslyation reactions invloved in elongation of peptidoglycan chains
Bactericidal

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3
Q

Vancomycin, Teicoplanin

A

Glycopeptide antibiotics

Narrow spectrum
Gram-positive
Infection caused by MRSA and PRSP
Clostridium difficile

Parenteral
Renal elimination

Chills, fever
Injection site phlebitis
Ototoxicity
Nephrotoxicity

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4
Q

Oritavancin

A

Glycopeptide antibiotic

Narrow spectrum
Gram positive
Tx severe skin infections

Parenteral
GI symptoms
Elevated liver enzymes
Elevated CK

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5
Q

Daptomycin

A

Lipopeptide antibiotics
Disrupt ionic gradients and membrane depolarization
Bactericidal effect

Narrow spectrum
Gram positive

Parenteral administration
Renal elimination

Pulmonary surfactant antagonizes daptomycin
So cant use for pneumonia tx

Myopathy
Pneumonitis

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6
Q

Bacitracin

A

Polypeptide antibiotic
Inhibition of peptidoglycan precursor translocation across the bacterial membrane
Bacteriostatic or bactericidal effect depending on the concentration of the drug

Gram-positive

Parenteral

Nephrotoxicity
Hypersensitivity

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7
Q

Fusidic acid

A

Miscellaneous antibiotics
Inhibits elongation factor G
Bacteriostatic effect

Gram-positice
Aerobes and anaerobes
Topical for skin infections
Systemic for MRSA infection

Topical/parenteral

Hepatotoxicity(with systemic use)

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8
Q

Mupirocin

A

Miscellaneous antibiotics
Inhibitis bacterial protein synthesis by selectively binding to isoleucyl-tRNA synthetase

Active against gram-positive cocci
Tx of impetigo caused by staphylococci, B-hemolytic streptococci, S.pyogenes
Intranasal ointment for eliminating nasal carriage of S. Aureus

Topical

Local itching and burning
Rash, erythema, contact dermatitis

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9
Q

Pharmacotherapy of skin and soft tissue infections. Skin and soft tissue infections

A

Cellulitis, impetigo
Topical: fusidic acid, mupirocin, colistin
Staph, strep: nafcillin IV, Oxacillin IV
MRSA: Vancomycin IV

Necrotizing fasciitis (Group A strep): Clindamycin IV and Penicillin G IV

Gas gangrene (C. Perfringens): Clindamycin IV and penicillin G IV

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