C/17. Glycopeptides. Fusidans. Lipopeptides. Bacitracin. Mupirocin. Pharmacotherapy Of Skin And Soft Tissue Infections. Flashcards
Drugs need to know in this topic
Vancomycin
Teicoplanin
Oritavancin
Daptomycin
Bacitracin
Fusidic acid
Mupirocin
Glycopeptide antibiotics
MOA
Binding at the D-ala-D-ala terinal of the nascent peptidoglycans pentapeptide side chains
->inhibits the transglycoslyation reactions invloved in elongation of peptidoglycan chains
Bactericidal
Vancomycin, Teicoplanin
Glycopeptide antibiotics
Narrow spectrum
Gram-positive
Infection caused by MRSA and PRSP
Clostridium difficile
Parenteral
Renal elimination
Chills, fever
Injection site phlebitis
Ototoxicity
Nephrotoxicity
Oritavancin
Glycopeptide antibiotic
Narrow spectrum
Gram positive
Tx severe skin infections
Parenteral
GI symptoms
Elevated liver enzymes
Elevated CK
Daptomycin
Lipopeptide antibiotics
Disrupt ionic gradients and membrane depolarization
Bactericidal effect
Narrow spectrum
Gram positive
Parenteral administration
Renal elimination
Pulmonary surfactant antagonizes daptomycin
So cant use for pneumonia tx
Myopathy
Pneumonitis
Bacitracin
Polypeptide antibiotic
Inhibition of peptidoglycan precursor translocation across the bacterial membrane
Bacteriostatic or bactericidal effect depending on the concentration of the drug
Gram-positive
Parenteral
Nephrotoxicity
Hypersensitivity
Fusidic acid
Miscellaneous antibiotics
Inhibits elongation factor G
Bacteriostatic effect
Gram-positice
Aerobes and anaerobes
Topical for skin infections
Systemic for MRSA infection
Topical/parenteral
Hepatotoxicity(with systemic use)
Mupirocin
Miscellaneous antibiotics
Inhibitis bacterial protein synthesis by selectively binding to isoleucyl-tRNA synthetase
Active against gram-positive cocci
Tx of impetigo caused by staphylococci, B-hemolytic streptococci, S.pyogenes
Intranasal ointment for eliminating nasal carriage of S. Aureus
Topical
Local itching and burning
Rash, erythema, contact dermatitis
Pharmacotherapy of skin and soft tissue infections. Skin and soft tissue infections
Cellulitis, impetigo
Topical: fusidic acid, mupirocin, colistin
Staph, strep: nafcillin IV, Oxacillin IV
MRSA: Vancomycin IV
Necrotizing fasciitis (Group A strep): Clindamycin IV and Penicillin G IV
Gas gangrene (C. Perfringens): Clindamycin IV and penicillin G IV