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PHARMACOLOGY SEMMELWEIS > C/14. Quinolones And Fluoroquinolones > Flashcards

C/14. Quinolones And Fluoroquinolones Flashcards

1
Q

Drugs need to know in this topic

A

Norfloxacin
Ciprofloxacin
Ofloxacin

Levofloxacin

Moxifloxacin

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2
Q

Fluoroquinolones

MOA

A

Direct inhibitors of nucleic acid synthesis
Interfere with bacterial DNA synthesis by inhibiting topoisomerase II
Bactericidal effect
Exerting post-antibiotic effect (PAE)

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3
Q

Fluoroquinolones

Pharmacokinetics/dynamics properties

A

Orally active

Renal excretion

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4
Q

Fluroquinolones

SEs

A 
GI distress
Skin rash
Phototoxicity
CNS effects
Hepatotoxicity
Tendinitis
QT prolongation
Teratogenic
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5
Q

2nd gen

A

Norfloxacin
Ciprofloxacin
Ofloxacin

Gram +, -
Mycobacteria
Atypical agents 
N. Gonorrhea
B. Anthracis
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6
Q

3rd gen

A

Levofloxacin

Less active against gram -
Extended activity against gram +
Community-acquired pneumonia

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7
Q

4th gen

A

Moxifloxacin

Similar to 3rd gen with extended anaerobic coverage(broadest spectrum)

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PHARMACOLOGY SEMMELWEIS (54 decks)

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