C/13. Aminoglycosides

Question 1

Aminoglycosides

MOA

Answer 1

Bind to the 30S ribosomal subunit and intefere with protein synthesis

(1) blocking formatio of the initiation complex
(2) inducing misreading of mRNA
(3) inhibiting translocation

Bactericidal effect
Exerting post-antibiotic effect(PAE)

Question 2

Aminoglycosides

SEs

Answer 2

Ototoxicity
Nephrotoxicity
Neuromuscular blockade
Allergic skin reaction
Teratogenecity

Question 3

Drugs need to know in this topic

Answer 3

Gentamycin
Tobramycin
Amikacin
Netilmicin

Streptomycin

Neomycin
Kanamyin

Question 4

Gentamycin
Tobramycin
Amikacin
Netilmicin

Answer 4

Aerobic gram negative; E.coli, enterobactoer, klebsiella, proteus, proteus, pseudomonas, serratia)
Commonly used in combination with beta-lactam antibiotics
-enterococci (with penicillin)
-pseudomonas(with 3rd gen cephalosporin)

Parenteral
Renal elimination
Dose reduction in renal impaiment

Resistant bacteria expressing acetyltransferase, inhibit drug
Alteration of ribosomal binding site
Intrinsic resistant

Question 5

Streptomycin

Answer 5

In combinatio with penicillin; tuberculosis, enterococcal endocarditis

Parenteral
Renal elimination
Dose reduction in renal impaiment

Resistant bacteria expressing acetyltransferase, inhibit drug
Alteration of ribosomal binding site
Intrinsic resistant

Question 6

Neomycin

Kakamycin

Answer 6

Used to suppress intestinal flora before bowel surgery
Topical use

Oral, topical

Parenteral
Renal elimination
Dose reduction in renal impaiment

Resistant bacteria expressing acetyltransferase, inhibit drug
Alteration of ribosomal binding site
Intrinsic resistant