Bullous pemphigoid

Question 1

Bullous pemphigoid

Answer 1

• autoimmune condition
• sup-epidermal blistering of skin
• secondary to development of antibodies against hemidesmosomal proteins BP180 and BP230
• more common in elderly

Question 2

Features of bullous pemphigoid

Answer 2

• itchy, tense blisters (often around flexures)
• blisters heal without scarring
• stereotypically no mucosal involvement (mouth is spared)
• biopsy showns IgG and C3 at dermoepidermal junction

Question 3

Management of bullous pemphigoid

Answer 3

• refer to derm for biopsy and diagnosis confirmation
• oral corticosteroids
• topical corticosteroids
• immunosuppressants
• antibiotics