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Dermatology > Acanthosis nigricans > Flashcards

Acanthosis nigricans Flashcards

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Dermatology Board Prep flashcards
1
Q

Acanthosis nigricans

A

Symmetrical brown, velvety plaques
Often found on neck, axilla, groin

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2
Q

Main causes of acanthosis nigricans

A
  • type 2 diabetes
  • GI cancer
  • obesity
  • PCOS
  • acromegaly, cushings
  • drugs (COCP, nicotinic acid)
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3
Q

Pathophysiology of acanthosis nigricans

A
  1. insulin resistance -> hyperinsulinaemia
  2. stimulation of keratinocytes and dermal fibroblast proliferation via interaction with insulin-like growth factor receptor 1 (IGFR1)
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Dermatology (58 decks)

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