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Breast Pathology Flashcards

1
Q

What are the two layers of cells in the breast?

A

luminal

myoepithelial

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2
Q

What drug is used to treat mastitis?

A

Dicloxacillin

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3
Q

What is periductal mastitis?

A

inflammation of the subareolar ducts

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4
Q

In what patient population is periductal mastitis usually seen?

A

smokers

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5
Q

What causes periductal mastitis?

A

lack of vitamin A

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6
Q

What is mammary duct ectasia?

A

inflammation with dilation of subareolar ducts

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7
Q

What is the high yield mechanism of how mammary duct ectasia often presents?

A

green/brown discharge

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8
Q

What type of patient with mammary duct ectasia likely arise in?

A

Multiparous postmenopausal woman

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9
Q

Presence of what type of cell on biopsy would confirm mammary duct ectasia?

A

Plasma

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10
Q

How does intraductal papilloma clasically present? Pre or postmenopausal?

A

bloody nipple discharge

premenopausal

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11
Q

Which cells are contained within a Intraductal Papilloma?

A

epithelial

myoepithelial

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12
Q

Which cells are contained within a Papillary Carcinoma?

A

epithelial

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13
Q

What two types of tissues are contained within a fibroadenoma?

A

fibrous and glandular

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14
Q

Are fibroadenomas seen more often in pre or post?

A

Premenopausal

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15
Q

Does a fibroadenoma have an increased risk for transforming into a carcinoma?

A

no

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16
Q

What is a phyllodes tumor?

A

fibroadenoma with fibrous overgrowth

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17
Q

Are Phyllodes tumors more often seen in premenopausal or postmenopausal women?

A

Post

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18
Q

What is seen on histology during a Phyllodes tumor?

A

‘leaf-like’ projections

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19
Q

How is DCIS often detected on mammography?

A

calcifications

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20
Q

What is Pagets disease of breast?

A

DCIS that has extended out of the nipple

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21
Q

What is invasive ductal carcinoma?

A

DCIS that has invaded basement membrane

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22
Q

What cell is lacking in a tubular carcinoma?

A

myoepithelial

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23
Q

What is the prognosis of Tubular Carcinoma?

A

good

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24
Q

Does mucinous carcinoma occur in young women or old women?

A

old women

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25
What is the prognosis or mucinous carcinoma?
good
26
What cells are present during a Medullary Carcinoma?
Lymphocytes and plasma cells
27
Which type of breast cancer is BRCA1 associated with?
medullary
28
What is inflammatory carcinoma characterized by?
carcinoma in dermal lymphatics
29
What can Inflammatory Carcinoma be confused with?
mastitis
30
What is the prognosis for inflammatory carcinoma?
poor
31
What type of breast cancer lacks E-Cadherin?
lobular carcinoma in situ
32
What is the Tx for LCIS?
tamoxifen
33
On histology, could could LCIS be distinguished from Invasive Lobular Carcinoma?
Invasive Lobular Carcinoma = signet rings
34
Which population has an increased incidence to develop triple negative breast cancer?
african american women
35
What cancers are BRCA1 associated with?
breast and ovarian carcinoma
36
What cancers are BRCA2 associated with?
male breast cancer
37
Where does male breast cancer present?
subareolar mass
38
Where is the highest density of breast tissue for males?
under the nipple
39
What is the most common type of male breast cancer?
invasive ductal carcinoma
40
Other than BRCA2, what genetic condition could lead to male breast cancer?
Klinefelters syndrome
41
The breast is a modified what type of gland?
sweat
42
What structure is the breast embryologically derived from?
skin
43
Which quadrant contains the most amount of breast tissue?
upper/outer
44
Which two parts of the breast tissue are lined by two types of epithelium?
ducts and lobules
45
Which two types of fibrocystic changes have have a 2x increase in breast cancer?
sclerosing adenosis ductal hyperplasia
46
Which type of fibrocystic changes have have a 5x increase in breast cancer?
Atypical hyperplasia
47
Does Intraductal Papilloma have underlying epithelial and myoepithelial cells?
yes
48
Does Papillary Carcinoma of the breast have underlying epithelial and myoepithelial cells?
no
49
Which breast pathology can present with a Blue Dome appearance?
Fibrocystic Change
50
Which two benign breast conditions can present with microcalcifications?
sclerosing adenosis fat necrosis
51
What type of carcinoma is Desmoplastic Stroma indicative of?
invasive ductal carcinoma
52
What breast cancer presents with cells in 'single-file'?
invasive lobular carcinoma
53
How does male breast cancer present?
subareolar mass
54
Can Galactorrhea be caused by Nipple Stimulation?
yes
55
What type of metaplasia takes place during Periductal Mastitis?
squamous
56
What happens to the terminal duct during Periductal Mastitis?
blockage
57
With what two ways does Periductal Mastitis present?
nipple retraction subareolar masss
58
Presence of what type of cell on biopsy would confirm fat necrosis of breast?
giant cell
59
Where do Fibrocystic Changes of the breast most often present?
upper/outer quadrant
60
Does Apocrine Metaplasia during Fibrocystic Changes carry an increased risk of cancer?
no
61
Which benign fibrocystic change can present with calcifications?
sclerosing adenosis
62
Of the fibrocystic changes that increase risk of breast cancer, which breast cancer is it?
invasive carcinoma
63
Of the fibrocystic changes that increase risk of breast cancer, is the risk for unilateral or bilateral breasts?
bilateral
64
Which breast cancer can present with bloody nipple discharge?
papillary carcinoma
65
Does Papillary Carcinoma of the Breast present in pre or postmenopausal womens?
post
66
Does DCIS produce a mass?
no
67
What are two histological characteristics of the Comedo type of DCIS?
necrosis dystrophic calcifications
68
Is Lobular Carcinoma unilateral or bilateral?
bilateral
69
What happens to the HER2/Neu gene during breast cancer?
amplification

Pathoma (19 decks)

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