Bovine-muscle pathology

Question 1

Features

Answer 1

1. Vitamin E - Se deficiency
   - loss of lipid peroxidation scavenger
   - loss of glutathione peroxidase activity in free radical enzymatic inactivation
2. Selenium antagonism (copper, zinc)
3. Nutritional overload with free radicals (unsaturated lipids)

Question 2

Classic lesion Vit E deficiency

Answer 2

Left ventricular multifocal myocardial necrosis with calcification

Question 3

Nutritional myopathy gross lesions

Answer 3

1. Heart: left ventricle most common
2. Skeletal muscle
   - weight bearing groups in thoracic/pelvic limb, intercostal and diaphragm
3. Suckling animals: tongue and neck

Question 4

Toxic muscle diseases

Answer 4

1. Plants: coffee senna - mostly skeletal m.

2. Ionophores: monensin, etc - skeletal and cardiac m. affected

Question 5

clostridial myositis

Answer 5

Blackleg: Chlostridium chauvoei

1. DNAases, hyaluronidase
2. Ush pelvic/pectoral m. also heart diaphragm possible
3. Fluorescent ab test