Botanicals - Cardiovascular Flashcards
How many CV botanicals listed for NPLEX2. Name as many as you can.
There are 19 botanicals for the Cardiovascular system. Allium cepa Allium sativum Capsicum frutescens Coleus forskohlii Commiphora mukul Cordylalis ambigua Crataegus oxycantha Digitalis purpurea Gingko bilboa Leonarus cardiaca Olea europea Plantago major Rauwolfia serpentina Scutellaria baicalensis Selenicereus grandiflorus Theobroma cacao Veratrum album/viride Vinca major/minor Viscum album/flavescens
Allium cepa indications
Internal:
Urinary infections: Urgency, pus, hematuria, stones
Elevated Cholesterol & platelet aggregation; elevated BP
Inhibits cyclooxygenase (COX) & lipoxygenase (LOX) therefore useful in inflammatory conditions
Elevated blood glucose in type 2 DM: ADPS competes with insulin for degradation sites in the liver
External (Topical):
dermatophytosis, onychomycosis, warts, vaginitis, otits media
Allium cepa CI
1) Hypothyroidism: Disulphides/allyl alcohols: Reduces iodine uptake by the thyroid (goitrogenic); if patients eat lots of raw onions, limit them as it may interfere with iodine uptake; cooked onions don’t have the goitrogenic effect.
2) Bleeding disorders, anticoagulant therapy
Allium cepa Interactions
Potentiates anticoagulants (warfarin), insulin, and hypoglycemic drugs (Metformin, Glyburide, Rosiglitazone)
Allium cepa constituents
Disulphides (ADPS, s-methyl csyteine sulfoxide) [Onions smell cause of sulpher]
Phenolic acids (caffeic, sinapic, p-courmaric) [onions are round shape]
Flavonoids (quercitin) [most vegetables have flavonoids]
Sterols, saponins, pectin, oils
Allium cepa actions
Hypoglycemic, antimicrobrial, carminitive
Allium cepa pharmacology
Active components (disulfides) give the tearing properties of onions but when heated active components are destroyed, caramelized onions have no more active components
ADPS: increases half life of insulin (due to competition at degradation sites), increases insulin secretion, increases hepatic metabolism of glucose.
Inhibits bacterial reproduction (staphylococcus spp.)
Reduces platelet aggregation
antioxidant for LDL cholesterol
decreases leukotrienes due to inhibition of COX and LOX
Allium sativum indications
Upper respiratory infections: cough, catarrh, pertussis, otitis media
intestinal parasites: worms; candidiasis
Hypercholesterolemia, hyperlipidemia [reduces serum cholesterol and triglyceride levels while raising high density lipoprotein’s - HDL]. It’s antioxidant properties help prevent the peroxidation of fats which is another factor in the development of atherosclerosis. Intermittent claudication; mild to moderate hypertension; prevention of heart attack and strokes.
Allium sativum caution
Therapeutic doses of garlic may potentiate the activity of anticoagulant medication’s.
Allium sativum Actions
Antimicrobial (antifungal, antiprotozoal, antibacterial) hypotensive, hypolipidemic
Allium sativum constituents
Alliin, diallyl disulphide
Capsicum frutescens Indications
Topical: diabetic neuropathy, pruritus, psoriasis, OA, RA, migraines
Internal: hypochlorydia, H pylori, maldigestion, dyspepsia, billary insufficiency, atonic constipation, artherosclerosis, G.I. or respiratory infection, hypercoagulation, Stimulant, capillary atoni.
Capsicum frutescens Contraindications
Pregnancy; due to G.I. upset, and leaf and stem act as uterine stimulant
Capsicum frutescens interactions
Cayenne compounds the persistent dry cough side effect of ace inhibitors lisinopril
Look at the word
ACEi
cApsiCum frutEscens and remember the cough in ACE inhibitors
Too much cayenne will definitely make you cough!
Capsicum frutescens constituents
Capsaicinoids (up to 1.5%): capsaicin, dihydricapsaicin, carotenoids; saponins
Capsicum frutescens Actions
Circulatory and vasomotor stimulant, rubefacient/counterirritant, gastric stimulant; antimicrobial
Capsicum frutescens pharmacology
Powerful circulatory and digestive stimulant
Lowers cholesterol triglycerides and LDL;:HDL ratio
Decreases platelet aggregation
Capsaicin binds to C type vanilloid receptor (VR1) and opens a cationic channel allowing the influx of calcium. The calcium influx is an excitatory response, which releases Neuro peptides (substance P) that is responsible for chemo genic pain, Thermo regulation and neurogenic inflammation. By binding to the VR1 receptor, substance P will be depleted, and pain transmission decreases. C-fibers are related to pain, not perception of touch, temperature and pressure.
Stimulates production of collagenase as an anti-inflammatory (osteoarthritis, rheumatoid arthritis)
coleus forskohlii indications
Asthma, dilated cardiomyopathy, hypertension, allergies, glaucoma, hypothyroidism, obesity
coleus forskohlii Contraindications
Active peptic ulcer, pregnancy, lactation, children
coleus forskohlii interactions
May potentiate caridac glycosides (digoxin, Convallaria, digitalis, leonarus), anticoagulants (warfarin), insulin and hypoglycemic drugs (metformin, glyburide, rosiglitazone), antihisamines (diphenhydramine, hydroxyzine, loratidine), levothyroxine
May increase bleed with NSAIDs (apririn, ibuprofen, napoxen, celecoxib) antagonize proton pump inhibitors (esomeprazole)
coleus forskohlii constituents
Diterpene glycosides
coleus forskohlii actions
Adenylate cyclase activator, positive iontropic, vasodilator, hypotnesive, bronchodilator, anti-inflammatory, hypoglycemic, antihistamine, anti-platlet
Commiphora mukul (indian bdellium, Guggul lipid) indications
Elevated LDL, hyperipidemia; inflammation (osteoarthritis); nodulocystic acne
Commiphora mukul (indian bdellium, Guggul lipid) contraindications
Inflammatory bowel disease
Commiphora mukul (indian bdellium, Guggul lipid) interactions
May induce CYP 450, may decrease bio availability of propranolol
Commiphora mukul (indian bdellium, Guggul lipid) actions
Hypolipidemic, anti-inflammatory
Commiphora mukul (indian bdellium, Guggul lipid) Constituents
Gugglusterone E, Z
Mukul = Guggul (sterone) E,Z
Commiphora mukul (indian bdellium, Guggul lipid) pharmacology
Increase hepatic binding sites for LDL
Inhibits cholesterol synthesis in liver; decreases triglycerides (does not work for all patients)
increases fecal excretion of bile acids and cholesterol
decreases pain of osteoarthritis after one month
Convallara majalis (lily of the valley) indications
Arrhythmia, cardiac insufficiency, hypotension
Convallara majalis (lily of the valley) contradictions
Digitalis spp. and caution with other cardiac glycosides
Convallara majalis (lily of the valley) side effects
Nausea, vomiting, headache, disorders of color perception, death
treat with atropine; monitor potassium, glucose, insulin
A girl is twirling in a valley of lilies. She twirls so fast that she starts to feel nauseas and vomits, she gets a headache but keeps spinning until she sees a discolored hue and she almost dies because she has an arrhythmia, hypotension and cardiac insufficiency.
Note: digoxin (Foxglove) has a s/e of yellow/green hue around objects.
Convallara majalis (lily of the valley) interactions
Avoid hypokalemic drugs; diuretics (furosemide, hydrochlorothiazide), corticosteroids (hydrocortisone, prednisone dexamethasone),
cardiac glycosides (digoxin Convallaris, digitalis Leonurus),
antiarrhythmics (atenolol, propranolol, amiodarone),
psuedoephedrine,
Glycyrrhiza
Calcium promotes arrhythmia, potentiates beta-blockers (atenolol, carvedilol, propranolol), many others
Similar to Cardiac glycosides: Convallaria majalis, digitalis purpurea, Leonurus cardiaca
Convallara majalis (lily of the valley) constituents
Glycosides, flavonoids
The lilies have a sweet smelling flavor for flavonoids
Convallara majalis (lily of the valley) actions
Cardiac, digitalis substitute, diuretic
Convallara majalis (lily of the valley) pharmacology
The power and speed of cardiac muscle contraction is increased with reduced relaxation time. Positive ionotropic, negative chronotropic (rate), negative dromotropic (conduction), positive bathmotropic (excitability) effect.
Natriuretic and diuretic in animal studies
dose-dependent venoconstrictive effects an animal tests
Corydalis spp (Corydalis cava, corydalis ambigua) indications
Used for pain management for severe nerve damage, emotional disturbances and tremors; used as a sedative and tranquilizer for high blood pressure and to relax spasms of the small intestines
Corydalis spp (Corydalis cava, corydalis ambigua) contraindications
Pregnancy and breast-feeding
Corydalis spp (Corydalis cava, corydalis ambigua) interactions
none reported
Corydalis spp (Corydalis cava, corydalis ambigua) side effects
Decrease menstrual flow, headaches, fatigue
Corydalis spp (Corydalis cava, corydalis ambigua) overdosage
Chronic spasms with musculature tremor occur with overdosages
Corydalis spp (Corydalis cava, corydalis ambigua) constituents
isoquinoline alkaloids (bulbocapnine, corytuberin, corydaline)
Corydalis a cord of alkaloids
remember isoquinoline
Corydalis spp (Corydalis cava, corydalis ambigua) actions
Mildly sedative, sleep inducing, spasmolytic, tranquilizing and hallucinogenic affect. It’s suppresses CNS, reduces blood pressure and decreases intestinal motility. Strong analgesic
Crataegus oxyacantha (Hawthorn) indications
Arrhythmias, cardiac weakness with valvular murmurs, capillary fragility, mild hypertension
Crataegus oxyacantha (Hawthorn) CI
N/A